Qingwenbaiduyin Drinking Observe The Clinical Efficacy In Patients With Sepsis, Some Effects Of Serum Immunoglobulin Indicators

Objective:To discuss the clinical efficacy and the affection to immunology of blood serum of Qingwenbaidu Fluid for pyemia disease.Methods:49 pyemia cases with intensive heat in both Qi and Ying phase type according to TCM syndrome differentiation were selected from ICU department of the teaching hospital of Chengdu University of TCM between Oct.2007 to Feb.2008. Randomization,single blinding and controlling method was used in this clinical experimental design.The total cases were divided into treatment group with 24 cases and controlling group with 25 cases randomly.Qingwenbaidu Fluid and the standard western therapy were applied to treatment group,while for controlling group,only regular western therapy were used to compare the clinical efficacy by the total scores of the TCM symptoms and the APACHEⅡassessment;and to observe the concentration change of IgG,IgA,IgM,C3,CRP,TNF-αin blood serum。Results:Compared to treatment group and controlling group,the effective probability is 70.83%for the former and 64.00%for the later.There is no significant difference between the two(P＜0.05).As to the total scores of the TCM symptoms and that of the APACHE assessment,there is significant statistic difference between the two groups.Conelusion:Qingwenbaidu Fluid combining regular western treatment is effective in treating pyemia.It is better than the controlling group in reducing the C3,CRP,TNF-a levels of blood serum.It's working on suppressing the over- response of the immune system,hence reduces its damage to the body itself,of which further research needs to be done to reveal its mechanism.