The Expression And Clinical Significance Of MTA1and BRMS1in Pancreatic Cancer

ObjectiveBy detecting expression of MTA1and BRMS1in pancreatic cancer tissues and cancer adjacent normal pancreatic tissues, to explore the correlation between these two indicators and their clinical application value in pancreatic cancer.MethodsThe expression levels of MTA1proteins and BRMS1proteins were tested by immunohistochemical method in41pancreatic cancer specimens and11cancer adjacent normal tissues, and the corelation analysis with clinical feature of patients was analyzed. All data were conducted by using SPSS17.0, Chi-squared statistic was used to analyze statistical significance. Differences were considered statistically significant at p<0.05. Spearman correlation was adopted to analyze the correlation between the expression of MTA1and BRMS1in pancreatic cancer.Results1. The percentage of MTA1positively expression was60.98%in pancreatic cancer tissues and18.18%in the adjacent normal tissues, statistical difference was found between them(P<0.05), The expression of MTA1was correlated with tumor pathological grades, clinical stage and lymph nodes metastasis (P<0.05),but there was not related to size of carcinoma, sex and age(P>0.05).2. The percentage of BRMS1positively expression was43.90%in pancreatic cancer tissues and90.91%in the adjacent normal tissues, statistical difference was found between them(P<0.05), The expression of BRMS1was correlated with clinical stage and lymph nodes metastasis (P<0.05),but there was not related to tumor pathological grades,size of carcinoma,sex and age(P>0.05).3. In pancreatic carcinoma, there was negative correlation between the expression of MTA1proteins and BRMS1proteins.(r=-0.401, P<0.05).Conclusion1. The increase of the expression in MTA1may was correlated to the occurrence, development and metastasis of pancreatic carcinoma;2. The Absence or decline of the expression in BRMS1may was correlated to the occurrence,development and metastasis of pancreatic carcinoma;3. In pancreatic carcinoma, there was negative correlation between the expression of MTA1and BRMS1.