Guliukang Granule In Treating Bone Metastases With Kidney Deficiency And For Effects Of Serum BSP

Objective:1) To observe the clinical efficacy on Guliukang granule combined withzoledronic acid in bone Metastases patients;2)To observe the influence of serum BSP onGuliukang granule combined with zoledronic acid in bone metastases，preliminarydiscussion Guliukang granule granule by inhibiting the expression of BSP serum andtreatment of bone metastases carcinoma.Methods: Select into standard of60patients with bone metastatic carcinoma.60patients, based on the principles of the distribution of the randomized, controlled, divide intothe treatment group and control group,30cases in each group. Treatment group withGuliukang granule receiving intravenous infusion of zoledronic acid，4weeks for a course；the control group of30cases,to receive intravenous infusion of zoledronic acid alone.Treatment after observing two groups of patients with degree of pain relief, quality of lifeindex changes, and the change of bone metastases, at the same time using biotin method ofdouble antibody sandwich enzyme-linked immunosorbent assay (ELISA) before and aftertreatment were detected the serum BSP, the results were statistically analyzed.Results:Before treatment, there were no significance between2groups in age, gender,primary disease, KPS score and serum BSP and TCM symptoms integral.After the treatment,the treatment group and control group has significant difference in pain and TCM symptomintegral (P<0.05); Treatment group patients quality of life index10cases had marked effect,17cases effectively; Control group3cases had marked effect,14cases effectively, afterstatistics analysis have difference (P<0.05);4weeks after treatment ends, in terms of bonemetastases recovery, treatment group had higher efficiency than control group, but there wasno significant difference(P>0.05); Patients in treatment group was significantly decreasedthe serum BSP (P<0.01), compared with the control group with significant difference (P<0.05).Conclusion:1)The Guliukang granules combined zoledronic acid treatment of bonemetastases carcinoma, can relieve and even complete pain relief, help to improve KPS score, improve the quality of life, improve the clinical curative effect;2) Joint guliukang granulesto phosphonic acid treatment of bone metastases carcinoma, can lower the serum BSP,inhibiting osteoclast mature, resulting in a protective effect of bone.