| ObjectiveAccording the clinic observation of the results, we objectively assess the clinical efficacy and safety of Jian Pi Hua Shi Qing Re Decoction via treating pre-diabetic patients, and then try to explore its possible mechanism.Methods60cases met the inclusion criteria were randomly divided into three groups with the method of randomized controlled trials.These groups are Control group (20cases)without any treatment, Chinese traditional medicine group (20cases) intervened with Chinese medicine Jian Pi Hua Shi Qing Re Decoction (one parcel, twice a day)and Western medicine group (20cases) intervened with Metformin (500mg Bid). The lifestyle treatment is no different among three groups. The changes of FPG,2hPG, HbA1c and clinical symptom integral of all cases were observed and compared at the end of the12th and24th.The data were analyzed with t-test and ANOVA of SPSS17.0.Results1. Compared with control group, FPQ2hPQ HbAlc and clinical symptom integral of Chinese medicine and Western medicine groups were significantly decreased (P<0.05) at the end of the12th week respectively (P<0.05). Compared with control group, FPG,2hPQ HbAlc and clinical symptom integral of Chinese medicine and Western medicine groups were significantly decreased (P<0.01) at the end of the24th week respectively (P<0.01). compared with Western medicine groups,FPQ HbAlc and insulin resistance of Chinese medicine groups were significantly reduced (P<0.05).2. Chinese medicine Jian Pi Hua Shi Qing Re Decoction significantly reduce the FPG,2hPQ HbAlc and clinical symptom integral before treatment in comparison with which of the end of the12th week (P<0.05). Chinese medicine Jian Pi Hua Shi Qing Re Decoction significantly reduce the FPG,2hPQ HbAlc and clinical symptom integral before treatment in comparison with which of the end of the24h week (P<0.01),3. Chinese medicine Jian Pi Hua Shi Qing Re Decoction significantly reduce the HbAlc and clinical symptom integral at the end of the12th week in comparison with which of the end of the24th week (P<0.05). 4. Security indicators such as blood routine test, liver and kidney function are normal during the entire experiment among three groups.ConclusionChinese medicine Jian Pi Hua Shi Qing Re Decoction combined with lifestyle treatment can significantly improve the glycometabolism and reduce the postprandial glycemia without the side effects of marrow, liver and kidney lesion as the similar effect of the metformin combined with lifestyle treatment. Furthermore, longer term (24weeks) effect of this treatment seemed to be better than that of shorter term (12weeks). Therefore, it shows that Jian Pi Hua Shi Qing Re Decoction combined with lifestyle treatment is effective. |
PDF Full Text Request