Clinical Observation Of Treatment Of Early Diabetes Therapy Function High Blood Glucose And Improve Islet Of Integrated Traditional Chinese And Western Medicine

Objective:The clinical research of this topic, to further explore the combination of traditional Chinese and Western medicine therapy in the treatment of diabetes early hyperglycemia and improve islet function, reduce the clinical efficacy of insulin resistance.Methods:Selected high blood glucose standard with type 2 diabetes,according to the level of islet function,which is divided into A ?high?, B ?low? two groups, A group including traditional Chinese medicine plus oral western medicine group ?treatment group A?, simple oral western medicine group ?control group A?; group B plus insulin group ?including traditional Chinese medicine treatment the treatment group B?, insulin group ?control group B?; 20 cases in each group. Giving regular treatment ?strict diet control, exercise, diabetes education and psychological adjustment?, treatment group A prescription to large doses of Qingrexiehuo with Amaryl,2-4mg qd, Acarbose,50-100mg tid, sitagliptin phosphate 100mg qd treatment; control group A to Amaryl 2-4mg qd, acarbose 50-100mg tid, sitagliptin phosphate 100mg qd; treatment group B prescription to high-dose Qingrexiehuo with insulin lispro ?Humalog?, insulin glargine ?Lantus? subcutaneous injection; control group B to insulin lispro ?Humalog?, insulin glargine ?Lantus? subcutaneous injection. Each process in the treatment of patients with blood glucose monitoring system, and timely adjustment of drug dosage according to the results of blood glucose monitoring.The results:1. Comparison of experimental results:Comparing the treatment group A total efficiency 90%, total effective rate of group A was 85%, by statistical analysis, no statistically significant difference between the integrated effect of the two groups ?P>0.05?; B treatment group total effectiveness 85%, control group B total efficiency of 65%, by statistical analysis, the two groups had statistical significance of comprehensive the curative effect difference ?P<0.05?.2. Glycemic control comparing:treatment group A at 1 week,4 weeks and 8 weeks after treatment, blood glucose control is more stable and safer, lower risk of hypoglycemia, better than the control group ?P< 0.05?, and is especially suitable for the control of 2hPG; especially in the first week of treatment after overall glycemic control effect is obviously superior to the control group A, showed that the treatment group A in a safe, rapid, glycemic control has significant advantages, the first week of treatment was the most obvious. The treatment group B in the treatment of 1 weeks,4 weeks and 8 weeks after the blood sugar control effect is better than the control group ?P<0.05?, especially in the treatment of first weeks, the blood glucose decreased more obviously, and the blood sugar fluctuation is small. In conclusion, A and B in the treatment group combined with traditional Chinese medicine treatment of blood glucose after a more rapid decline, low volatility, a lower risk of hypoglycemia, the hypoglycemic effect is more stable and safer, especially suitable for the reduction of 2hPG.3. Islet function comparison:after 8 weeks of treatment, the insulin resistance index and insulin secretion index of the treatment group and the contrast group before and after the comparison between the results before and after the treatment group compared to the treatment group ?P<0.05? than the control group ?P₂>0.05?; after treatment, the comparison between the two groups ?P₁<0.05 group than the control group ?P₂>0.05??, the difference was statistically significant. Note, A and B in the treatment group after treatment with traditional Chinese medicine, can effectively reduce insulin resistance, improve insulin sensitivity, and promote the repair of islet beta cell function partly, so as to effectively reduce the use of hypoglycemic drugs and insulin dosage, more convenient to patients; in addition, the difference in traditional Chinese Medicine in the treatment of islet function. The role of targeting will differ in islet function can improve the Homa- ?, the effect is more obvious, while in poor islet function, improve the Homa-IR effect is more obvious.4. Improve the TCM clinical symptoms compared to all patients after symptomatic treatment, thirst, bitter breath, upset impatience, eat easy to hunger, hand and foot fever, fatigue, more frequent urination, and uncomfortable or difficult knot, red tongue spent Tianjin and other clinical symptoms were significantly improved, with statistical significance ?P<0.05?; show the comparison between the two groups, the treatment group A in improving TCM clinical symptoms and reduce the symptoms quantify integral than the control group A, there were significant differences ?P<0.05?, B treatment group in relieving clinical symptoms, improve the quality of life was significantly better than the control group B, there was significant difference ?P<0.01?.5. Safety results:during the course of the experiment, drugs were no obvious adverse reactions of patients in each group, there is clinical significance of the abnormal index results did not show clinical examination, according to the clinical medication safety was high, no obvious side effects?Conclusion:In the method of traditional Chinese medicine combined with western medicine in early stage of diabetes oral compound reuse Qingrexiehuo the glycemic control clinical curative effect, can fast and smooth control of blood glucose, blood glucose fluctuation is small, low risk of hypoglycemia, and can significantly alleviate clinical symptoms, improve the quality of life, but also shows the Chinese medicine in reducing insulin resistance, great the benefits of promoting the function of islet beta cell repair and Improve the secretion function of pancreatic islets, so as to effectively reduce the type and dosage of hypoglycemic drugs, open up new ideas and methods for clinical diagnosis and treatment of patients with diabetes mellitus.