The Study Of Clinical Observation On Kidney Invigorate The Circulation Of LUFS In Infertility

ObjectiveUteinized unruptured follicle syndrome (LUFS) can be usually observed in ovulation induction cycle with clinical application of clomiphene citrate (CC). This study applies the methods of Bushen Huoxue TCM cycle therapy and injection of human chorionic gonadotropin(hCG), individually and collectively, to the patients’ovulation induction cycle.By observing the before and after treatment effect of traditional Chinese medicine symptoms, numbers and size of follicles, the changes of ovarian blood flow, the pregnancy rate and adverse reactions after treatment, this study compares the treatment effects and summarizes a safe, effective and reasonable ovulation inducing method, providing clinical basis to reduce the occurrence rate of LUFS and increase the pregnancy rate.MethodsRandomly divide a total of60infertile patients receiving treatment in our hospital from March2013to March2014who suffer LUFS after applying CC to stimulate oyulation into three groups, respectively, A, B and.C groups, with20patients in each group. During the period of ovulation induction cycle with CC, patients of A group were treated with Bushen Huoxue TCM cycle therapy and group B were with injection of hCG, while the C group were treated with a combination of the above-mentioned two methods. After3consecutive menstrual cycles, B ultrasound monitoring indexes including numbers and size of follicles, ovarian blood flow parameter, the pulsatility index (PI), resistance index (RI),peak systolic velocity (PSV), Chinese medicine syptoms changes and pregnancy would be collected and the before and after index changes would be analyzed with statistics.Results1. TCM syndrome score:No statistical difference of scores were observed among three groups of patients before treatment (P>0.05). After treatment, by comparison, there was significant difference between A group and B group (P<0.01) and C group and B group (P<0.01). Meanwhile, A group and C group showed no significant difference (P>0.05); Comparing scores of before and after treatment, A group and C group scores were significantly different (P<0.01), B group had no statistical difference (P>0.05).2. Results:Clinical symptoms of three groups of patients after receiving treatment were observed to have statistically significant (P<0.05). Compared A group with B group, there was statistically significant difference (P<0.05); Compared C group with B group, there was statistically significant difference (P<0.05); Compared A group with C group, no significant difference was observed(P>0.05).3. Ovulation:Ovulation rate and follicular number of three groups of have significant statistical differences (P<0.01). Comparing A group and B group, there was statistically significant difference(P<0.05). Comparing C group with B group, statistical significant difference was observed (P<0.01). Comparing A group with C group, there were no significant difference (P>0.05). No difference between the follicular diameter of three groups was observed(P>0.05).4. The pregnancy rate of three groups:the pregnancy rate had.significant difference(P<0.05). Comparing A group with B group, there was statistically significant difference (P<0.05). Statistically significant difference was also observed between C group and B group(P<0.01), Comparing A group with C group, there was no significant difference (P>0.05).5. Ovarian artery hemodynamics effects:There was no statistical difference (P>0.05) concerning three groups patients’ PI, RI, PSV in the first cycle of treatment. After three treatment cycle, there was statistically significant difference (P<0.01) concerning A and C groups’ blood flow of ovarian and that of B group. Before and after treatment, A group and C group had significant difference (P<0.01) concerning blood flow of ovarian. There was also statistically significant difference (P<0.05) of B group concerning its blood flow of ovarian in the periovulatory period.There was statistically significant difference (P<0.05) when comparing Group A and group C concerning blood flow of function and non functional side of ovary in the periovulatory period, but no statistical difference of group B’s bilateral ovarian blood flow were observed(P>0.05).6. The reoccurrence rate of LUF:there was statistically difference comparing A and B groups(P<0.05); Comparing C and B groups, there was statistically difference concerning ovulation rate (P<0.01); There was statistically difference (P<0.01) comparing A and C groups.7. Ovarian hyperstimulation syndrome (OHSS) in each group:in the treatment process OHSS was not observed.Conclusion1. Bushen Huoxue TCM cycle therapy, either used individually or together with hCG, can improve the symptoms of LUFS patients.2. The application of Bushen Huoxue TCM cycle therapy to ovulation induction cycle with CC, is observed to deliver a better effect than that of hCG group concerning stimulating ovulation, and at the same time, can improve the egg quality significantly.3. Bushen Huoxue TCM cycle therapy can improve ovarian blood flow in different period while hCG can only improve ovarian blood flow in the periovulatory period.4.Bushen Huoxue TCM periodic therapy can improve the pregnancy of infertile women with LUFS, and the effects become better as drug time lasts longer.5. Bushen Huoxue TCM cycle therapy can deliver a significant effect to reduce the reoccurrence rate of LUF.