| Objective:This study used tonifying kidney and inducing ovulation recipe plus Human chorionic gonadotropin(HCG)to intervene patients diagnosed with ovulation disorder infertility during ovary stimulation cycles,to observe the clinical effect of the method,and to explore its possible mechanism,so as to provide clinical reference for the treatment combined Chinese and western medicine of ovulation disorder infertility,and looking for a new method and train of thought for the treatment of ovulation disorder infertility.Method:According to the principle of random and contrast,ninety-five patients diagnosed with ovulation disorder infertility which met the inclusion criteria were divided into Treatment group(Yishen ovulation + HCG qroup,32 cases),control gpoupl(simple HCG group,31 cases)and control group2(Xuefuzhuyu oral liquid + HCG group,32 cases).From the fifth day of the menstrual cycle,all the patients take letrozole(LE,2.5mg/d)for 5 days.At the same time,they should take the nourishing-yin recipe.Using transvaginal ultrasound to monitor the follicular diameter,then add human menopausal gonadotropin(HMG)to induce the maturation of dominant follicle.When the follicle diameter?16mm,give the patients appropriate intervention.Taking supplementing-yang recipe after confirming the ovulation,Until the menstruating or pregnancy.Then comparing the three groups of dominant follicle's quality and ovulation conditions.the incidence of buteinized unruptured Follicles(LUFS).pregnancy rate.abortion rate?ovarian artery blood flow.thickness of endometrium?clinical symptoms of TCM score,and to explore the mechanism of Yishen ovulation recipe in treating ovulation disorder infertility.Results:?The ovulation rate?incidence of LUFS of the treatment group were 76.25%and 13.75%,while the control groupl were 49.41%?29.41%and the control group2 were 65.0%?20.0%.There were significant differences in the ovulation rate?incidence of LUFS between treatment and controll groups(P<0.05).?The treatment group included 14 pregnant patients,1 case of abortion,the pregnancy rate was 46.7%;the control group 1 included 6 pregnant patients,1 case of abortion,the pregnancy rate was 20%;the control group2 included 7 pregnant patients,1 case of abortion,the pregnancy rate was 24.1%.There were no significant differences in the pregnancy rate(P>0.05),it may be associated with the small sample size.There were no significant differences in the abortion rate(P>0.05).?There were no significant differences in the rate of single-follicle developmeng cycles of treatment grooup was 63.75%compared with 56.47%?56.25%of control groupl and 2(P>0.05).There were significant differences in the quality of follicle after treatment between treatment and contro11?contro12 groups(P<0.05).?There were no significant differences in the qovarian artery blood flow of pulsation index?resistance index?peak systolic velocity/end diastolic velocity before treatment between treatment and contro11?contro12 groups(P>0.05),and there were significant differences after treatment.?There were significant differences in the thickness of endometrium on the day of ovulating,of treatmeng grooup was 9.19±0.68 mm compared with 8.57±0.50 mm.8.49±0.55mm of control groupl and 2(P<0.05).After comparing one to another,there were significant differences between treatment and controll groups?treatment and contro12 groups(P<0.05).?The numbers of recovery?remarkable effect?effect and inefficacy of the treatment group were 18?7?3and 2,and the total effective rate was 83.3%,while the control group1 was 76.7%and the control group2 was 86.2%.The total effective rate in the treatment group was higher than those in the control groups,but the differences was not statistically significant(P>0.05),it may be associated with the small sample size.?The three groups before treatment?after treatment of clinical symptoms of TCM score showed no statistical significance(P>0.05),the three groups before and after treatment of clinical symptoms of TCM score were statistically significant(P<0.05).Three groups of clinical symptoms of TCM score were significantly improved more than 80%.Conclusion:In the principle of " invigorating the kidney and promoting blood circulation,disperse blood stasis and dredge collateral",seizing the period of "dihou",then using tonifying kidney and inducing ovulation recipe plus HCG to intervene patients diagnosed with ovulation disorder infertility during ovary stimulation cycles,it can significantly increase the ovulation rate,reduce the incidence of LUFS,improve the quality of follicles and ovarian artery blood flow,promote the high quality follicles mature and ovulate,and promote the growth of endometrium,thus obtaining a satisfactory rate of pregnancy.The tonifying kidney and inducing ovulation recipe is based on reinforing kindey to strengthen yin,activiting biood to promote menstrution,making yin-yang balance of organism,qi-blood smoothing,Viscera function,and improve the clinical symptoms of TCM. |
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