The Study Of The Correlation With Hypertension Dialectical Classification And Melatonin

ObjectiveObserve serum melatonin level differences in hypertension classification、 risk stratification、different syndromes、the main difference between the symptoms, discuss its correlation with the syndrome of hypertension and high blood pressure.MethodCollect244cases of hospital outpatient and inpatient subjects, including184cases of patients with hypertension, normal group of60patients. According to the table to ask the main clinical symptoms observed in patients, according to the diagnostic criteria will be divided into hyperactivity hypertension, liver and kidney, yin and yang, Qi phlegm four syndromes. Collect patient self-test blood pressure registered in family, about8:00am to9:00patients blood pressure testing, and patient blood samples collected, placed1hour at room temperature, centrifuged blood samples extracted serum, and make cryopreservation. Use Enzyme-linked immunosorbent assay test human melatonin levels, melatonin levels was observed across the four syndromes, the main symptoms, hypertension classification, the difference between hypertension risk stratification.Results1184cases observed in hypertensive patients according to the symptoms listed in Table23, and more than40%of the10main symptoms are dizziness, forgetfulness, nocturia, shortness of breath, backache, insomnia, tinnitus, dry mouth, headache, chest tightness, the top five of vertigo (63.5%), forgetfulness (60.8%), nocturia (55.9%), backache (47.2%), insomnia (47.2%).2Hypertensive patients according to the presence or absence of dizziness, forgetfulness, nocturia, shortness of breath, backache, tinnitus, dry mouth, headache, chest tightness and other symptoms of10divided into two groups, the difference between the presence or absence of a comparison group of melatonin statistically significant statistical results Tip all P values greater than0.05, not statistically significant. Integration of clinical symptoms grouped (symptom score and symptom score≤10>10) between the two groups was not statistically significant.3Basic information on184cases of hypertensive patients, namely gender, age, family history (Table3-Table5), grouping, melatonin levels differences between comparison groups, including sex groups, family groups serum melatonin level difference was not statistically significant. But age group younger than40years old age group compared with the40to60age group, P=0.001<0.05, a statistically significant difference. Younger than40years of age group>60years age group and age, P=0.001<0.05, a statistically significant difference.40to60age group and age>60years age group, P=0.02<0.05, the difference was statistically significant.4The prevalence of hypertension in patients with age, hypertension, blood pressure classification, risk stratification of hypertension, blood pressure control is standard when collecting specimens and blood pressure values measured melatonin levels correlated with a statistical analysis of the results (table6-table11) show that the normal control group, the age of hypertension (N)≤1groups, respectively N>1(1<N≤5,5<N≤10, N>10) other3compared to the group, serum melatonin levels were higher than the three groups, and the difference was statistically significant;3difference in serum melatonin levels N>1is not statistically significant. Hypertension a normal group with two, three groups were compared, P<0.05, the difference was statistically significant,2and3comparison, P>0.05, the difference was not statistically significant. Compared with the normal group EH grade1, P<0.05, a statistically significant difference. Low-risk group, the control group, respectively, the high, very high-risk group3, P<0.05, a statistically significant difference. The remaining two groups t test, P>0.05, the difference was not statistically significant. Compliance or not with the differences in blood pressure control between melatonin levels was not statistically significant. When collecting specimens measured diastolic, systolic and melatonin levels were not correlated. Serum melatonin levels observed in hypertension classification, risk stratification, different syndromes, the main difference between the symptoms discussed with hypertension and syndromes are relevant.5Qi deficiency and phlegm normal control group and the group were higher than melatonin yang, yin and yang, liver and kidney deficiency group, and statistical significance. Normal control group and the group phlegm qi melatonin levels showed no statistically significant.Conclusion1. The main symptoms of hypertension and demonstrated how clinical symptoms and serum melatonin levels may be no significant correlation.2. In hypertensive patients in age, gender, family history and whether the general case, age is one of the factors in serum melatonin levels influence. Serum melatonin levels observed in hypertension classification, risk stratification, different syndromes, the main difference between the symptoms discussed with hypertension and syndromes are relevant.3. Blood pressure in hypertensive patients with melatonin levels are not necessarily inversely related, this study has not been involved in circadian regulation, it can not be confirmed with the circadian rhythm of melatonin correlation. For blood pressure, hypertension and a low-risk patients, melatonin may to some extent involved in the regulation of blood pressure and protect the target organ, with patient age, the prevalence increased age, risk factors for growth, faded melanin levels decline, and the protective effect of this regulation is not obvious.4. The results of this study indicate that the normal control group and the group phlegm qi melatonin levels were higher than yang, yin and yang, liver and kidney deficiency group, and statistical significance. Normal control group and the group phlegm qi melatonin levels showed no statistically significant. This study shows that melatonin may be one of modern medicine, traditional Chinese medicine theory test in clinical indicators innate essence reaction, the reaction may decrease melatonin levels in patients with hypertension severity of liver and kidney deficiency. Serum melatonin levels observed in hypertension classification, risk stratification, different syndromes, the main difference between the symptoms discussed with hypertension and syndromes are relevant.