| Background and objectiveVitiligo is a common dermatological disorder characterized by primary, regional or generalized, depigmented skin macules. It dues to the chronic and progressive decrease or loss of melanocytes. The epidermis, mucous membranes, retina and hair bulbs can be totally involved.Generally the race owes the deeper colour has the higher incidence, and the incidence of the yellow race is between the white race’s and the black race’s. Large population surveys have shown that the incidence is0.1～2.7%and all races can be involved in China. It may affect the quality of life in patients with vitiligo and make a difference to the patients’normal learning, employment, marriage, family and social interaction. The exact aetiology of vitiligo remains obscure, possible etiologic factors include heredity, nerve, spirit, melanocyte self-destruction, autoimmunity, cytokines, free radicals and relative lack of trace elements, etc. Recently many surveys have indicated that vitiligo is closely associated with autoimmunity. The patients with vitiligo often have autoimmune thyroid diseases, alopecia areata, diabetes, systemic lupus erythematosus, etc, especially autoimmune thyroid diseases. In the present survey, according to analysis and quantify the quality of life and detect the level of the serum thyroid autoantibodies in patients with vitiligo, it aims to assess the influence on quality of life of patients and investigate the relationship between vitiligo and autoimmune thyroid diseases. Materials and methods1.100patients with vitiligo who enrolled in the questionnaire survey were out-patients in the Department of Dermatology of the First Affiliated Hospital of Zhengzhou University during2012.8-2013.3.40patients with vitiligo who enrolled in the study on the levels serum thyroid autoantibodies were out-patients during2012.10～2013.3.40patients were classified into two groups:progressive stage group (26cases) and stationary stage group (14cases). Of the patients,21were men and19were women, aged from6to55. The mean age of onset was27.08±10.86years. All the patients were not taken treatment last month and have no complication.38normal individuals served as controls. Of the controls,20were men and18were women, aged from5to56. The mean age of onset was28.74±9.49years.2. We evaluated the effect of vitiligo on quality of life in patients by DLQI.3. We measured the levels of TPOAb and TGAb by chemiluminescent immunoassay.4. Statistics process:All the statistical analyses were performed by the SPSS17.0software package and all the data are expressed with X±S. The results of DLQI were carried by one-way ANOVA and corresponding epidemiological factors were carried by Spearman correlation analysis. The comparisons of the positivity of TPOAb and TGAb between every two groups were carried by chi-square test. The inspection level is a=0.05.Results1.100patients with vitiligo were enrolled in the questionnaire survey and98questionnaires were valid.The mean score of DLQI was7.80±5.30. It displayed that vitiligo had moderate effect on quality of life of patients. The quality of life of42.86%patients had a little effect. The quality of life of28.57%patients had moderate effect. The quality of life of25.51%patients had significant effect. During the groups of universal type, scatter type, topical type, acral type and segmental type, the DLQI score of universal type group was highest (P<0.05). The DLQI score of scatter type group was higher than topical type group’s (P<0.05). The DLQI score of progressive type group was higher than stationary type group’s (P<0.05). In the scores of DLQI, there were no statistical differences in the sex and degree of education. The scores of DLQI and the areas of lesions had positive correlation (Spearman=0.611). The disease duration, age and age of onset were all not related to the scores of DLQI.2. The positivity of TPOAb and TGAb in the serum of patients with vitiligo was higher than that in controls significantly. The positivity of TPOAb in patients with vitiligo was25.00%, higher than that in controls (2.63%for TPOAb, P<0.05). The positivity of TGAb in patients with vitiligo was22.50%, higher than that in controls (5.26%for TGAb, P<0.05). The positivity of TPOAb and TGAb in female patients with vitiligo was higher than that in male patients (P<0.05). The positivity of TPOAb and TGAb in patients with vitiligo in21～30years old was higher than that in patients with vitiligo in the other age (P<0.05). In the different clinical classification and clinical stage, there were no statistical differences in the positivity of TPOAb and TGAb in patients with vitiligo (P>0.05)Conclusions1. Vitiligo had moderate effect on quality of life of patients. The clinical types and stages had certain influence on patient’s life. The scores of DLQI and the areas of lesions had positive correlation. In the clinical work, dermatologists should pay attention to the influence on quality of life in patients with vitiligo.2. The positivity of TPOAb and TGAb in the serum of patients with vitiligo were higher than that in controls obviously. The positivity of TPOAb and TGAb in young female patients with vitiligo was high. Clinicians should be aware of the risk of the concurrence of vitiligo and autoimmune thyroid disease, and ensure early screening, early detection and early treatment. |
