| Objective: According to the principle of matching the age and gender, 482 patients with vitiligo were selected by stratified random sampling, and 106 healthy people were selected as the control group. The serum levels of T3, T4, fT3, fT4, TSH, TGAB, TPOAb and other thyroid function indexes in serum was detected by chemiluminescence immunoassay and According age, sex, vitiligo in different stages, classification and Uyghur Medical abnormal hilit type to Making comparisons, analysis of the relationship between thyroid function and vitiligo abnormal hilit type.Method: The 482 vitiligo patient has been selected in the Department of Dermatology Uyghur medical hospital of the Xinjiang autonomous region,The 106 healthy control has been selected in the same hospital Who taken to Thyroid function test.Fasting venous blood 5ml, static at room temperature 1h,marked with the name and number, save at 80 degrees refrigerator,in 1 week to detection and record the results down. Under the Wood lamp、skin CT examination to determine the vitiligo patients type, according to the history of vitiligo patients to determine the stage,according to Uyghur medical hilit type parsing table and two Uyghur medical experts evaluate to determine the vitiligo patients abnormal hilit type.Finally, all the data recorded,using multivariate statistical ways to analysis of the relationship between thyroid function and vitiligo abnormal hilit type.Result: Completed a total of 482 cases in vitiligo group,106 cases in control group.There was no significant difference in the mean age, age distribution, population sex ratio between the two groups and Have good comparability(P>0.05).There were significant differences in ethnic composition between the two groups(P<0.05), the largest in the Uyghur nationality, and the second in the Han nationality.There was no significant difference in the distribution of vitiligo in patients with differentsex in the case group(P>0.05). Different gender patients Uyghur Medicine abnormal Hilit type distribution have significant differences, which in female patients with Shor balgham(P = 0.01). Many men with Kirtak balgham type(P<0.01). But there was no significant difference between the Tamsiz balgham type and Gajsiman balgham type.The positive rates of TGAB and TPOAb were 11.2% and 21.8% in the observation group, which were significantly higher than those in the healthy group of 1.9% and 4.8%(P=0.002 and0.001). There was no significant difference between the Kirtak balgham type in patients with non Kirtak balgham type in patients with TGAB and the positive rate of TPOA(p>0.05).There was no significant difference between the positive rates of TGAB and TPOAb in patients with different clinical types of vitiligo(p>0.05). There was no significant difference in the positive rates of TGAB between Different age groups(P>O.05). The positive rate of TPOAb in vitiligo18-45 age group was significantly higher than that of healthy groups(P<0.01). Kirtak balgham type T4、T3、FT4 were significantly higher than that of non Kirtak balgham type vitiligo patients(P<0.05).Vitiligo group T3,T4 and FT3, FT4 levels were significantly higher than the normal group(P<0.01). In addition, there was no significant difference in the level of TSH between the two groups(P>0.05). The level of FT4 in patients with acral vitiligo were significantly higher than those of other clinical types(P<0.01).Conclusion: The positive rate of TGAB and TPOAb in patients with vitiligo was significantly higher than that of healthy people. TPOAb positive rate of 18-45 years old patients with vitiligo was significantly higher than that of the healthy people of the same age group, this illustrated Vitiligo is often associated with autoimmune thyroid disease, and the high incidence of 18-45 age.Kirtak balgham type T4、T3、FT4 were significantly higher than that of non Kirtak balgham type vitiligo patients.The level of FT4 in patients with acral vitiligo were significantly higher than those of other clinical types.The abnormal rate of T3 and FT3 in vitiligo group was significantly higher than that in normal group. this illustrated The detection of thyroid function in patients with vitiligo has important clinical significance, And the Kirtak balgham quality may affect the degradation of thyroid hormone or It may be the main cause of vitiligo and abnormal thyroid function,This requires further research. |
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