| BackgroundMild acute pancreatitis is one of common acute abdomen surgery disease, and the incidence rate of it is from80%-85%of occupied the whole acute pancreatitis. For this disease, medical treatment for simple monotonic, expensive treatment cost, longer treatment time. The disease in the treatment by surgical operation treatment to non operation treatment and conservative. In the current clinical treatment, it has become an important method for treatment of this disease with integrated traditional Chinese and Western medicine, but it is not clear of the mechanism of traditional Chinese medicine in the treatment of acute pancreatitis. This topic through the use of conventional treatment of Western medicine combined with oral Dachaihu decoction, dynamic observation of Dachaihu Decoction on acute pancreatitis (i.e., acute pancreatitis of liver qi stagnation type) in patients with serum interleukin-1beta (IL-13), interleukin-6(IL-6) effect of concentration index changes, study the possible mechanism of Dachaihu Decoction in the treatment of mild acute pancreatitis patients of liver qi stagnation type.ObjectiveAccording to the efficacy of traditional Chinese medicine and pharmacology of features of Dachaihu decoction, observe the impact of IL-1β and IL-6in serum of peripheral blood using Dachaihu Decoction plus medical therapy on the patients with mild acute pancreatitis, evaluation of the clinical effect of Dachaihu Decoction Treatment of mild acute pancreatitis, to explore the possible mechanism of Dachaihu decoction treatment of mild acute pancreatitis, and provide a theoretical basis for the Chinese medicine treatment of mild acute pancreatitis.Methods41clinical cases in accordance with the inclusion criteria and exclusion criteria were collected, the41cases were randomly divided into treatment, group and control group,20cases in the control group, the treatment group of21cases. Two groups of patients during Hospitalization besides regular examination, then the serum IL-β/IL-6examination. Two groups in age and course of disease, IL-β/IL-6initial concentration, the proportion of men and women have no obvious difference.20cases in control group were given the basic treatment of Western medicine, with Dachaihu Decoction and21cases in the treatment group in the above treatment methods, the first day of the two groups were observed in patients before treatment (i.e. two groups are not taking drugs), treatment for third days, fifth days of treatment, patients with IL-1changes in peripheral blood serum beta and IL-6concentration on day seventh. To establish a database, using SPSS17.0statistical analysis, statistical methods for repeated measurement:variance with t test, chi square test and single factor statistical analysis. P<0.05, there was significant difference.Results3days of treatment, the IL-β and IL-6concentrations of the two groups were significantly lower, compared with before treatment, after statistical analysis, the difference was statistically significant (P<0.01); and the treatment group in peripheral blood serum IL-β and IL-6concentration reduced significantly more than the control group, the difference has statistical significance (P<0.05). For the fifth day, the IL-β and IL-6concentration of two group decreased significantly, and compared with the third day treatment, the difference was statistically significant (P<0.01); and the treatment group in peripheral blood serum IL-β and IL-6decreased more than the control group, the difference was statistically significant (P<0.01). On the seventh day, the serum IL-β, IL-6concentration of the treatment group and compared to it5days treatment without significantly decreased, without significant difference (P>0.05), with no significant differences between the treatment group and the control group (P>0.05); the control group treatment of7days and control group of5days, the difference was statistical significance (P<0.01).ConclusionsBy syndrome differentiation of traditional Chinese medicine, the TCM syndrome type (i. e., stagnation of liver qi stagnation type) corresponds to the patients, the use of conventional Chinese medicine (decoction) combined with western medicine treatment of mild acute pancreatitis on serum IL-1β and IL-6concentration reduced significantly, Dachaihu decoction can reduce the concentration of interleukin-1β, interleukin-6in peripheral blood serum of mild acute pancreatitis in patients with liver qi stagnation to improve acute inflammatory reaction. Proved by Dachaihu decoction combined with western medicine routine method can effectively remove inflammatory factor circulant produced in the treatment of severe acute pancreatitis, helps to reduce tissue damage, prevent disease, help the immune function recovery, has certain effect on the treatment of mild acute pancreatitis of liver and qi stagnation type. |
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