Analysis Of Risk Factor, Etiology And Prognosis In Multiple Cerebral Infarct In Young Adult

Object The aim of this study was to explore risk factors, etiology and near future prognosis of multiple ischemic stroke in young adults.Methods Total71young patients suffering with brain infarction were engaged in this study, accepting hospitalization (from Sept,2011to July,2013) in the First Affiliated Hospital of Kunming Medical University. All patients were separated into single cerebral infarction (SCI) group (29) and multiple cerebral infarction (MCI) group (42). Vessel risk factors and etiology of patients was exactly assessed and classified according to TOAST. The degree of neurological function defect at hospital admission was assessed by NIHSS, and the prognosis evaluated by modified Rankin Scale at3month after stroke onset. According to type of data, chi-square test, t test, rank-sum test and Logistic regression analysis was used to compare difference of risk factors, etiology and prognosis between SCI and MCI group.Results Result suggested that male gender was the most common risk factor [74.65%(53/71)], followed by hypertension [64.79%(46/71)], smoking[54.93%(39/71)] and hyperlipidemia [49.30%(35/71)]. Result of Logistic regression analysis suggested that hypertension (OR=3.48,95%CI1.52～7.97, P=0.01) and cardiac disease history (OR=2.30,95%CI1.10～4.84, P=0.03) was independent risk factors of MCI. The major etiology of SCI group and MCI group had significant difference (x2=8.99, P<0.05), The major etiology of SCI was LAA [44.83%(13/29)], SAA [24.14%(7/29)] and cardiac embolism [13.79%(4/29)], but the major etiology of MCI was LAA [30.95%(13/42)], SUE [26.19%(11/42)] and SAA [23.81%(10/42)] Lesion numbers (OR=23.4,95%CI1.44-379.47, P=0.03), NIHSS score (OR=23.4,95%CI1.44～379.47, P=0.03) was the independent factor associated with unfavorable prognosis in young ischemic stroke patients revealed by Logistic regression analysis.Conclusions The etiology and risk factor of MCI differ from SCI, hypertension and cardiac disease history was independent risk factors of MCI. The major etiology of MCI was LAA, SUE and SAA. Lesion numbers and NIHSS score was the independent factor associated with unfavorable prognosis in young ischemic stroke patients.