Cardiolipin Antibodies In Young And Middle Cerebral Infarction Etiology

Objective :To explore the role of serum anticardiolipin antibodies (ACA)among young and adult cerebral infarction as a risk factor.Methods : 1) Trial design based on case control study about matching group; 2) Statistics methods: single variable analysis do with t-test,χ2-test,rank sum test,multiple variable analysis do with non conditional logistic regression; 3) Serum ACA (Ig-G Ig-M) were determined by half-quantity ELISA.Result : 1) Age and sex is not a statistical significance (P>0.05); 2) The simple factor analysis showed that the risk factors for young and adult cerebral patients was related to body mass index, hypertension, hepertriglyceridemia , hepercholesterolemia, stroke family history, drinking, smoking, ACA; data showed a statistical significance (p<0.05). 3) Variables in logistic regression showed hypertension, stroke family history, drinking, smoking, hepertriglyceridemia, hepercholesterolemia, ACA are association with young and adult cerebral infarction,have a statistical significance(OR>1,more OR 95%CI not include 1;P<0.05;OR is 4.215,4.649,2.163,2.858,2.152,1.724,1.999 individually); but body mass index are not association with young and adult cerebral infarction,have not a statistical significance(OR>1,butOR 95%CI include 1;P>0.05). 4) ACA has interaction with hypertension, smoking(API is 52.3%,21.2%individually).Conclusion : 1) ACA is raletive with young and adult cerebral infarction patients before adjust the other risk factor; 2) ACA is valued as a more important risk factor for young and adult cerebral infarction patients by multiple factor analysis, 3) ACA has interaction with hypertension, smoking in statistics.