Clinical Research Between Carotid Atherosclerosis And Homocysteine In Hypertensive Patients

Objective1. To clear that whether high homocysteine is an independent risk factor foratherosclerosis.2. To explore the factors that influence high homocysteine.MethodsSelect715cases of hypertension patients, in March2013to March2014to thefirst affiliated hospital of nanchang university of cardiology clinic. inspection such ascarotid artery ultrasound、homocysteine、blood lipid、blood sugar、kidney functionwere all done. According to the results of carotid artery ultrasound，divide into thenormal group333cases, and382cases of carotid atherosclerosis group.Multi-factorunconditioned Logistic regression analysis was performed to analyze Diversity indexof two groups.Results1.Carotid atherosclerosis group of age, systolic blood pressure, time history ofhigh blood pressure, blood sugar, low density lipoprotein cholesterol (hdl-c), uric acid,homocysteine, smoking rates are higher than normal group of their carotid arteries,difference have statistical significance （P≤0.05）,Multi-factor unconditionedLogistic regression analysis had statistical significance（P<0.05）.2.Hcy concentrations were multiple plaques> twin plaques> single plaquegroup,The difference was statistically significant (P <0.05).3. Smoking and non-smoking, male and female, high uric acid and normal uricacid between the difference was statistically significant (P <0.05), homocysteine agewas significantly greater than normal homocysteine, the difference was statisticallysignificant (P <0.05).Conclusions1. Homocysteine is a independent risk factor of atherosclerosis.2. In this experiment homocysteine and the number of plaques were positivelycorrelated. 3. Age, gender, smoking, uric acid,as factors that influence plasma homocysteinelevels.