| Objective:To study the expression of tumor metastasis associated1(MTA1) and suppressor gene KISS-1in the pancreatic cancer and explores its relationship with the pathological indicators. Therefore we can build a foundation for their potential use as new treatment targets or important biological markers in the prediction, diagnosis, prognosis and treatment of pancreatic cancer.Methods:The immunohistochemical Envision two-step method was used to detect the MTA1and KISS-1protein expression in36cases of pancreatic cancer tissue and10cases of normal paracancer tissue.Results:The positive expression rate of MTA1in pancreatic cancer was77.8%(28/36), which was significantly higher than the20.0%(2/10) in the normal paracancer tissue (P<0.01); The positive expression rate of KISS-1in pancreatic cancer was90.0%(9/10), which was significantly lower than the90.0%(9/10) in the normal paracancer tissue (P>0.01). The expression of both genes were unrelated to the patient age, gender and tumor location (P>0.05), but related to the differentiation degree of cancer tissue, lymph node metastasis and clinical stage (P<0.05). In the pancreatic cancer tissue, the expression of MTA1and KISS-1were negatively correlated with each other (r=-0.533, P<0.01).Conclusion:MTA1and KISS-1are related to the occurrence, invasion and metastasis of pancreatic cancer and therefore are expected to become new treatment targets or be used as important biological markers in the prediction, diagnosis, prognosis and treatment of pancreatic cancer. |
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