Clinical Study Treatment Of Heat Tonglin Huoxue Stasis Chronic Prostatitis Randomized Placebo-controlled

BackgroundChronic prostatitis is a inflammatory diseases of the genitourinary system which is more common in young man. It is caused by pathogen infection such as microorganisms or some other non-infectious factors which stimulate the prostate. Its common clinical manifestations include two categories:voiding symptoms and pain or discomfort symptoms. Among them, voiding symptoms manifested urinary frequency, urgency, dysuria, urinary burning, or spilling a small amount of milky white liquid from the urethra occasionally, etc, and pain and discomfort symptoms mainly conclude the lower abdomen’s, perineum’s, lumbosacral’s, and groin’s pain or discomfort. Chronic prostatitis generally do not pose a threat to the lives of patients, but it can seriously affect the quality of life of patients. Some scholars believe that50percent of men may be affected by prostatitis at some stage in their life.Chronic prostatitis’s etiology is very complex, which includs pathogen infection, urine reflux, immune abnormalities, histopathology, neuroendocrine abnormalities, physical and chemical factors stimulating, genetic characteristics change, pelvic venous disease, oxidative stress increased, zinc content decreased, antibacterial activity of inhibiting factor for prostate and psychological factors, etc. Therefore, at present the majority of scholars are more inclined to think that it is a form of expression or a combination of disease which has its own unique syndrome, rather than a separate disease, and this syndrome each have unique clinical features, etiology and outcome.Chinese medicine believes that the etiology and pathogenesis of chronic prostatitis is mainly for kidney-oriented, hot and humid as the standard, stasis as changing, and pay more and more attention to the role of liver depression. And it put chronic prostatitis into four kinds of syndromes, as heat Accumulation, Qi stagnation card, Yin Huo-wang and deficiency loss.Recent studies have found that there are little patients with chronic prostatitis showing a single syndromes. Most patients is complex syndromes, and the maximum is patients of heat stasis type. therefore, HuoxueTonglin came into being.PurposeObserve and evaluate the efficacy of HuoxueTonglin to the patients with chronic prostatitis of heat stasis type.MethodThe study included80cases of male subjects from the Beijing University of Chinese Medicine, Dongzhimen Hospital who is in line with the Western diagnostic criteria of chronic prostatitis, TCM standards of heat stasis type and met the inclusion criteria, does not meet the exclusion criteria. Randomly assign these80cases to the experimental group of60patients and the control group of20patients. Give Longbixintong Granules to zhe experimental group as a treatment and placebo granules to the control group. At the14day and the28doy of the study, make the relevant checks and calculate NIH-CPSI score and TCM symptom score to evaluate the efficacy.ResultThe study included80patients as60cases of the experimental group and20cases of the control group. Finally the experimental group completed54cases, and the control group completed20cases, as74cases altogether. In the experimental group, cured2cases, the cure rate is4%; markedly effective in36cases, the markedly effective rate is67%; effective in9cases, the effective rate was16%; ineffective in7cases,13%; total effective number of cases was47, the total efficiency87%. In the control group, cured0cases, the cure rate is0%; markedly effective in2cases, the markedly effective rate is10%; effective in3cases, the effective rate was15%; ineffective in15cases,75%; total effective number of cases was5, the total efficiency25%. Using Wilcoxon rank sum test to test the NIH-CPSI score, TCM symptom score data of the experimental group showed that the difference between before treatment and after treatment was statistically significant (P<0.001). It means a significant effect of Longbixintong Granules on patients. As the same, the difference between before treatment and after treatment of the control group was statistically significant too(P<0.001). It means that placebo have a certain effect on patients. Using Mann-Whitney U rank sum test to test the difference between the experimental group and the control group on the difference between before treatment and after treatment of the NIH-CPSI score, TCM symptom score data showed that it was statistically significant (P<0.001). It means that Longbixintong Granules effect better than placebo. The result also showed that Longbixintong Granules effect significantly in improving the pain or discomfort, urination, impact and quality of life of chronic prostatitis patients with heat stasis type. It also did better in improving the symptom such as urinary frequency, more than Lek, urethral burning, perineal pain, abdominal pain, lumbosacral pain, testicular pain, scrotal wet, dripping white. But it had little effect in improving the thigh pain.ConclusionLongbixintong Granules effect better than placebo. Longbixintong Granules effect significantly in improving the pain or discomfort, urination, impact and quality of life of chronic prostatitis patients with heat stasis type. It also did better in improving the symptom such as urinary frequency, more than Lek, urethral burning, perineal pain, abdominal pain, lumbosacral pain, testicular pain, scrotal wet, dripping white. But it had little effect in improving the thigh pain. As the symptom of thigh pain occurs rarely, it has no statistically significant.In summary, HuoxueTonglin effect significantly on chronic prostatitis patients with heat stasis type.