Treating Kidney Tiaogan Stagnation Therapy Of Parkinson's Disease And Depression Were Observed In Disease Treatment

BackgroundParkinson’s disease is a kind of the nervous system degenerative diseases which occured in middle-aged and elderly people. Parkinson’s disease have two major clinical manifestations.One is the motor symptoms which contain a static tremor, muscle rigidity, bradykinesia and abnormal gait posture.Another is the non-motor symptoms which contain depression, constipation, sleep disorders and hidrosis. Depression is a common symptom of the non-motor symptoms. Depression can increase the cognitive impairment and disability of Parkinson’s disease patients. Parkinson’s disease has a high incidence of depression.As a consequence,in recent years, the depressive symptoms of Parkinson’s disease have drawn more and more attention.Drug therapy,which is deemed to have many side effects and which effect will wear off with the long-term drug curative, is the main treatment method to cure Parkinson’s disease depression.Traditional Chinese medicine for Parkinson’s disease with depression showed a better curative effect in clinical treatment based on recent clinical studies. Parkinson’s disease is a kind of disease belongs to "fibrillation card".At present, a lot of traditional Chinese medicine treatment methods have been used as the basic solutions to cure the Parkinson’s disease with depression.Teacher liu combined with her clinical diagnosis and treatment experience put forward that the disease also can be treated by the therapy of yishentiaoganjieyuliaofa, which is more applicable to Parkinson’s disease with depression.ObjectiveThis study aims to preliminarily investigate the clinical curative effect of the therapy of yishentiaoganjieyuliaofa for Parkinson’s disease with depression.MethodThis study adopts the method of randomed,single-blind,positive controled trial.42cases of Parkinson’s disease patients with depression were randomly divided into two groups, with21cases in each group.Treatment Plan:The trial group:basic medical treatment&yishentiaoganjieyuliaofa,time for2months;The control group:basic medical treatment&yangxuerouganliaofa,time for2months.Basic medical treatment: The patients who suffer from the original hypertension, hyperlipidemia, diabetes and so on keep its previous medication regimen; The patients who have adopted western medicine for curing the Parkinson’s disease can maintain the original scheme,the scheme can be adjusted on the drug types or doses according to the second edition of "Chinese Parkinson’s disease medication guide".ResultsThe change of the scores of UPDRS-III reveals that:Before and after the therapy, there are no differences within and between these two groups (P>0.05).The change of the scores of HAMD are consistent with the scores of SDS:Before and after the therapy,the scores are all decline within these two groups (P<0.05).The degree of the decline in the trial group is greater than the control group at the end of the first month (P<0.05), the degree of the decline are equal in these two group at the end of the second month (P>0.05).The change of the scores of HARS reveals that:Before and after the therapy, the scores are all decline within these two groups (P<0.05). The degree of the decline in the trial group is greater than the control group(P<0.05).The change of the scores of SAS reveals that:Before and after the therapy, the scores are all decline within these two groups (P<0.05). The degree of the decline in the trial group is greater than the control group at the end of the first month (P<0.05), the degree of the decline are equal in these two group at the end of the second month (P>0.05).The change of the scores of PDSS reveals that:Before and after the therapy, the scores are all rise within these two groups (P<0.05). The degree of the rise in the trial group is greater than the control group at the end of the first month (P<0.05), the degree of the rise are equal in these two group at the end of the second month (P>0.05).The change of the scores of MMSE reveals that:Before and after the therapy, there are no differences within and between these two groups (P>0.05).The change of the scores of PDQ-39reveals that:Before and after the therapy, the scores are all decline within these two groups (P<0.05). The degree of the decline in the trial group is greater than the control group at the end of the first month (P<0.05), the degree of the decline are equal in these two group at the end of the second month (P>0.05).ConclusionsThe improvement of yishentiaoganjieyuliaofa on the depression,anxiety and sleep is faster than the yangxuerouganliaofa.The therapy is beneficial for the improvement of the quality of life.However, this improvement are not parallel with the improvement of the motor symptom. It is necessary to further explore the curative effect mechanism,find the best treatment of the disease and perfect the standard clinical treatment standards.