Related Factors Young Men With Type 2 Diabetes Bone Density

Objective: To study and analysis the correlation of the check index andbone density in middlie-aged and young male patients with type2diabetes,provide the basis for studying the pathogenesis of diabetic osteoporosis.Methods: Review the records from2012January to2012December inDepartment of Endocrinology which belongs to the Affiliated Hospital ofLiaoning University of Traditional Chinese Medicine, according to theinclusion and exclusion criteria, we collected in61cases of malepatients with type2diabetes, and recorded the age, course of disease,height (H), body weight (W), fasting plasma glucose (FPG), fasting Cpeptide, postprandial30minutes,60minutes,120minutes C peptide,glycosylated hemoglobin (HbA1c), and bone mineral density(BMD),T value.Then, we use SPSS17.0statistical software for one-way ANOVA, correlationanalysis, to explore the effect of different indexes on bone mineraldensity.Results: We collected61cases of patients, aged34~60years old,according to the T value divided into Normal bone mass group of15casesof T (25%); Osteopenia group of36cases (59%); Osteoporosis group10cases(16%), the age, course of disease, and BMI of three groups showed nosignificant difference (P>0.05). Comparison of fasting blood glucose,glycosylated hemoglobin in three groups: Osteoporosis group> Normal bonemass group, Osteoporosis group>Osteopenia group, there was significantdifference (p<0.05), Normal bone mass group and the Osteopenia group hasno significant difference (P>0.05); C peptide secretion: Osteoporosisgroup <Osteopenia group, there were significant differences (p<0.05),there were no significant differences between the Normal bone mass groupand the Osteopenia group, Osteoporosis group (P>0.05); the insulinsensitive index of HOMA-IR (CP) in the three groups had no significant difference (P>0.05); comparison of ln (HOMA-β (CP): Osteoporosis group<Normal bone mass group, Osteoporosis group <Osteopenia group, therewere significant differences (p<0.05) Normal bone mass group andOsteopenia group had no significant difference (P>0.05). Correlationanalysis showed: Patients’ bone mineral density was positivelycorrelated with BMI (p<0.05), and negatively correlated with glycosylatedhemoglobin, fasting blood glucose (p<0.05), LN and lnHOMA-β (CP) werepositively correlated (p<0.05)Conclusion: Most of Young and middle-aged male patients with type2diabetes mellitus have osteopenia or osteoporosis; hyperglycemia is riskfactors caused by decreased bone density; high body mass index andfunction of islet beta cells are protective factors of bone mineraldensity.