The Changes Of Bone Density And Analysis Of Relevant Factors In Male Patients With Type2Diabetes Mellitus

Accompany with the development of industrialized society and the comingof aging era, the prevalence of diabetes increased year by year. Diabetescombined with osteoporosis also gradually become the focus of the two bighealth problems in the word. Because of the pressures of long-term sicknessdisadvantaged for the improvement of the quality of life and treatment, madepatients appear depression and loss of self-esteem, subjective happiness feelswas decrease. Diabetes combined with osteoporosis mainly displays in threeaspects: high risk, high mortality rate, high treatment costs. Foreign statisticalshows that accounted for50%,domestic statistics shows that diabetes patientswith osteoporosis incidence of more than50%.Diabetes combined withosteoporosis fracture made mortality rate and mortality rate of cardiovascularevents increased, both chronic diseases need long-term treatment. Huge of thecost of treatment brought heavy pressure and burden to the family andsociety.The results was exactly of type1diabetes can cause bone loss andosteoporosis.Because the pathogenesis was different between type1diabetesand type2diabetes, and the effect on bone metabolism produce wasdifferent,lacked of uniform conclusion in the changes of bone density andrelevant factors in male patients with type2diabetes.Our study choose patientswith type2diabetes for research, male didn’t suffer from menopause affect.The main trial was to explore the mechanism of type2diabetes combined withosteoporosis，to provide the reference diabetic osteoporosis prevention.Objective：To explore the changes of bone density and relevant factors inmale patients with type2diabetes mellitus.Research Methods:We choose68male patients with T2DM hospitalized in jilin university first hospital Endocrine Department from March2010toDecember2010，the age range from40to70years old，the average age of52.85years，and the history of diabetes for1-20years.We measured height andweight, calculated out body mass index,used automatic glycated hemoglobinanalyzer determine glycated hemoglobin,used double antibody sandwichABC-ELISA method to determined the insulin like growth factor-1and insulinlikegrowth factors binding protein3,and used the LUNAR type double canX-ray bone mineral density measuring instrument measured bonedensity.According toosteoporosis diagnosis standard divided into3groups,bonemass normal group,osteopenia group and osteoporosis group.Used SPSS13.0statistical software for statistical analysis,the statistical results indicatedby(x±s)，used single factor analysis of variance，between the two groups werecompared with SNKq test，the factors influence of BMD used the multiplecorrelation analysis.P <0.05means the difference has statistical significance.Results:1.Compared with the three groups, the relevance ratio ofosteopenia was49%, the relevance ratio of OP was22%.2.Compared with bonemass normal group, bone mineral density decreased obviously with L1、L2、L3、L4、L1-L4、Neck、Wards triangle、great trochanter and total in osteopeniaand osteoporosis groups（P<0.01).3.Compared with osteopenia group,bonemineral density decreased not obviously with L2and great trochanter inosteoporosis group，did not find significant differences（P>0.05）.4.Comparedwith the three groups,bone mass in ward triangle was less then other parts(P﹥0.05).5.Compared with bone mass normal group，HbA1c in osteopenia groupincreased significantly（P<0.01）.6.Compared with osteopenia group,HbA1cinosteoporosis group did not find significant differences（P>0.05）7.High BMIwas the Protective factorsin maintaining bone mass，Compared with the threegroups did not found statistical significance（P>0.05）.8.IGF-1、IGF-BP3、 age and course of disease havedid not found statistical significancewith bonemass （P>0.05).9.The multivariate analysis shows:Age and neck have anegative correlation.BMI has a positive correlation withL4、L1-L4、Neck、greattrochanter and total，HbA1c and L2have a negative correlation.10.IGF-1、IGF-BP3and course of disease have no relationship with bone mass.Conclusion:1.The bone mass in male patients with T2DM were lowerthen the nomal male without diabetes.2.Along with the increase of age,neckand wards triangle may be important region at observation bone mass loss inmales T2DM patients.3.Blood sugar control has an important impact on theearly OP in male T2DM patients.4.Males with T2DM should be maintained inthe appropriate level of BMI.5.This experiment did not find correlationbetween the male T2DM patients with bone mineral density of IGF-1andIGF-BP3.