Clinical Observation Of Traditional Chinese Medicine Sequential Therapy Of Children Bronchial Asthma

Objects: This study was to observe the clinical curative effect of traditional Chinesemedicine (TCM) sequential treatment of children bronchial asthma, mainly evaluate forthe changes of Chinese medicine symptom integral C-ACT score, and at the same timedetection the level of serum eosinophil cationic protein (ECP), immunoglobulin E (IgE)and pulmonary function. Preliminary discussion on the mechanism of action oftraditional Chinese medicine (TCM) sequential treatment of childhood bronchial asthma,and to provide a safe and effective prevention and control of traditional Chinesemedicine.Methods: In this study standard of CBA with60cases, were randomly divided intotreatment group and control group,30cases in each group, a course of6months. In thetwo groups were divided into episodes before treatment, remission before treatment,remission after treatment of a total three times. Observe two groups the index changesbefore and after treatment. In addition, select30cases in our hospital for medicalchecks of healthy children as healthy controls.Result:（1）Clinical efficacy: the total effective rate of treatment group is93.3%, thecontrol group is76.7%.The difference of two groups was statistically significant (P <0.05). C-ACT scores and TCM symptoms integrals were improved, the treatment groupis better than that of control group (P <0.05).（2）The treatment group and the controlgroup both can improve pulmonary function (PEF, FEV1and FVC), and the treatmentgroup is better than that of control group (P <0.05).（3）The treatment group andcontrol group episodes before treatment, remission before treatment serum ECP valuedifference has no statistical significance (P>0.05).The remission after treatment issimilar between the two groups have significant statistical significance (P<0.01).Thetwo groups of remission before treatment, remission after treatment compare toepisodes before treatment ECP values are decreased, the difference has statisticalsignificance (P<0.05).（4）The treatment group and control group episodes before treatment, remission before treatment serum ECP value compared with healthy controlgroup difference was statistically significant (P<0.05);Treatment group in remissionafter treatment compared with the health control group had no significant specificity(P>0.05).Control group in remission after treatment compared with healthy controls stillhave statistical significance (P<0.05).(5)The treatment group and control groupepisodes before treatment, remission before treatment serum IgE value difference is notsignificant (P>0.05), but compared with remission after treatment has difference(P<0.05). Two groups of three treatment times compared respectively, the differenceswere statistically significant (P<0.05).(6)The treatment group and control groupepisodes before treatment, remission before treatment serum IgE values compared withhealthy controls, the difference was statistically significant (P<0.05); The treatmentgroup and control group in remission after treatment compared with healthy controlshas no significant difference (P>0.05).Conclusion:(1) Traditional Chinese medicine (TCM) sequential therapy can makechildren with bronchial asthma TCM symptom score decreased, C-ACT score rise,point out that medicine sequential therapy can effectively improve the patient’s clinicalsymptoms.(2)Traditional Chinese medicine (TCM) sequential therapy can effectivelyimprove pulmonary function (PEF, FEV1and FVC) levels.（3）Bronchial asthma inchildren with ECP, IgE levels higher than normal children, prompt ECP and IgEelevated is associated with the onset of the CBA.（4）Traditional Chinese medicine(TCM) sequential therapy can effectively improve the abnormal bronchial asthma inchildren with higher ECP, IgE level. Sequential therapy of traditional Chinese medicinefunction mechanism could be by lowering its level, to reduce the eosinophil granulocyteinfiltration, reduce airway allergic inflammation, relieve airway inflammation andreduce airway hyperresponsiveness (AHR), and reach the purpose of treatment ofbronchial asthma...