The Correlationship Study Of DHEAS、T/E₂with MS In Pre And Postmenopausal Women

Objective:To study the correlationship of the dehydroepiandrosterone sulfate,serum testosterone and estradiol with metabolic syndrome in pre and postmenopausal women.Methods:Hangzhou Yu-huang-shan community women274cases,Who over40,were routine examination in hangzhou tumor hospital in March2012,eliminate interference factors, selected206cases,which were divided into5groups with reference to PENN-5stages defined,74cases of menstruation (group A),33cases of menopausal transition (group B),31cases of early menopause (group C),23cases of middle-late menopause (group D),45cases of late menopause (group E), group A as control group,111all cases of menopause (group F). Collected general data such as height, weight, menstruation, etc. and serum specimens, and in place-80零refrigerator, with batch testing in clinical laboratory of obstetrics and gynecology hospital affiliated to zhejiang university school of medicine.test indexes such as dehydroepiandrosterone sulfate (DHEAS), estradiol (E2), serum testosterone (T) and triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL-C), low density lipoprotein (LDL-C), fasting blood glucose (FBG), fasting insulin (FIN). apolipoprotein-Al (Apo-A1);apolipoprotein-B(Apo-B);lipoprotein-a(Lpa).Results:Dehydroepiandrosterone sulfate, serum testosterone and estradiol present a downward,The increasing trend of serum testosterone/estradiol, prompted androgen levels relative increase in postmenopause, the difference was statistically significant (P<0.05).TG was begin increasing in menopausal transition, declining in early postmenopause.TC,LDL-C increasing in postmenopause, declining in late menopause.HDL-C was declining in postmenopause, otherwise inclining in middle-late menopause,which were not statistically significant difference between each stage of postmenopause (P>0.05). Fasting blood glucose, fasting insulin levels rising in post-menopause, Which were not parallel, fasting insulin increased more obviously, prompted resistance to insulin. DHEAS was significant negative correlation with FBG (P<0.05), which as well as was significant negative correlation with TC,LDL-C(P<0.01,P<0.05), otherwise, no-correlation with TG,HDL-C. T/E2was significant positive correlation with TG,TC,LDL-C,FBG(P=0.000<0.01). Apo-A1,Apo-B and Lpa present a upward in post-menopause, the difference was statistically significant in pre and postmenopause (P<0.05),There was not statistically significant difference between each stage of postmenopause(P>0.05);Apo-A1was significant positive correlation with HDL-C (P=0.000<0.05),Apo-B was significant positive correlation with LDL-C(P=0.000<0.05).Conclusion:Androgen activity increase in postmenopausal women, as well as resistance to insulin. Dehydroepiandrosterone sulfate, serum testosterone may be involved in the metabolic syndrome collaborative estradiol in postmenopausal women.