The Relationship Between Dehydroepiandrosterone Sulfate (dheas ) And Arteriosclerosis In Patients With Type 2 Diabetes Mellitus

[OBJECTIVE]To investigate the correlation between dehydroepiandrosterone sulfate and arteriosclerosis in patients with Type 2 diabetes mellitus.[METHODS]Fifty-four patients with Type 2 diabetes mellitus in hospital were selected. All diabetic patients with type 2 were divided into four groups:the group DM1 was composed of male without vascular disease,the group DM2 was composed of male with subclinical vascular disease, the group DM3 was composed of male with clinical vascular disease,the group DM4 was composed of female patients.DHEAS was measured by chemiluminescence, ABI and baPWV were mesured by using the automatic measuringinstrument atherosclerosis VP-1000.[RESULT]1,The levels of serum DHEAS can be seen decresed as vascular lesions incresed in male patients..2,All cases of male were divided into two groups according to the levels of baPWV,such as:the group of normal baPWV,and the group of arteriosclerosis.The discrepancy was significant between them(P<0.05).All subjects were divided into two equal groups according to serum DHEAS levels.As to baPWV,there was significant discrepancy between the two groups (P<0.05).3,Serum levels of DHEAS were significantly negatively correlated with baPWV in male subjects only or all subjects.It is suggested that DHEAS is an independent risk factor of arteriosclerosis in male patients by Logistics multiple stepwise regression procedure(P<0.05).4,Serum levels of DHEAS were significantly negatively correlated with age and SBP, whereas positively correlated with BMI and smoking in male subjects.[CONCLUSIONS]The reduce of serum DHEAS might be an independent risk factor for arteriosclerosis.monitoring the level of serum DHEAS can predict the risk of arteriosclerosis in male patients of type 2 diabetes.