Urinary Smooth Capsule On The Urethral Syndrome In Women After Menopause, Clinical And Experimental Research

Objective: This trial is to observe the influence of the capsule called Niaochangshu on womb' s weight,the Estradiol in blood serum and urethra smooth muscle of female rat, as well as to explore its possible role in the mechanism further.Methods: 1.40 post-menopause urethral syndrome female of Chengdu University of TCM from March 2005 to September 2005 were divided into 2 groups randomly: treated group and control group, with were taken Niaochangshu collocyst and Nilestriol pill respectively, and after a month observe the clinic syndrome. 2. The sixty childhood female rats of the Kunming special will be divided into five groups: the blank group, the masculine group, and the highest dose group, the middle dose group, the lowest dose group of the Niaochangshu. Take Nilestriol pills and theNiaochangshu collocyst for intragastric administration. Then give theabove rat experimental medication per day a week. Last sacrifice the ratsand measure the wombs' weight. 3. From the eighty SD female rats sieve twenty estrus rats for blank group. The rest rats will be modeled and sieved fifty diestrus rats, which will be divided into five groups:the modle group, the masculine group, And the Niaochangshu highest dose group, middle dose group, lowest dose group. Use Estradiol Valerate pills and Niaochangshu collocystis for intragastric administration. Then give the above rat experimental medication per day in ten days. Then from the twenty rats sieves the proestrus rats as a blank group. Last from the fossa orbitalis of rats measure the Estradiol in blood serum. Ending sacrifice the rats and take urethra tissue, following HE staining and using the light microscope observe the urethra smooth muscle.Results: 1. Niaochangshu capsule can relieve the patient of urination syndrome. 2.Niaochangshu high dose group increase childhood female rat 's womb's weight. 3. Niaochangshu high dose group raise the estradiol in blood serum of castration rats. There is a statistical difference between the Niaochangshu high dose group and the model group. Niaochangshu high dose group may has effects on urethra smooth muscle and promote it reparation of castration rats.Conclusion: Niaochangshu collocyst boost the estrogen level of the female rats in experiment. Niaochangshu collocyst which can relieve the patient of urination syndrome has effects Mucous membrane of urethra and promote smooth muscle fiber reparation.