The Association Between Gingival Crevicular Fluid Interleukin-6, Serum Estradiol Status And Periodontitis In Early Menopause

Objective: The purpose of this investigation was to analyze by cross-sectional design the association between GCF Il-6 level, serum E2 level and common clinical measurements of periodontitis in Uyghur postmeno-pausal women. Methods: Forty-nine moderate/severe chronic periodontitis patients (including 34 E2-deficient subjects and 15 E2-sufficient subjects) and 30 non-periodontitis subjects, all within 5 years after menopause, completed the study. 30 GCF samples were harvested from healthy sites of 30 non-periodontitis subjects, 49 GCF samples from chronic periodontitis sites of 49 chronic periodontitis subjects. Clinical measurements of each tooth were recorded after obtaining GCF samples. GCF IL-6 and serum E2 levels were measured by 125I radio-immunoassay (RIA). Results: The mean concentration of GCF IL-6 from healthy sites was 1088.10±102.33pg/ml.The mean concentration of IL-6 from chronic periodontitis sites was 2961.22 ± 224.80pg/ml, significantly higher than that of healthy sites (P<0.005). Positive correlation was found between GCF IL-6 level and clinical measurements (GI, PPD and CAL) (r=0.564, P<0.005; r=0.335, P<0.05; r=0.324, P<0.05). Clinical measurements and GCF IL-6 levels of chronic periodontitis subjects were not differentbetween E2-deficient and E2-sufficient subjects. Conclusions: These findings suggest that there are lower IL-6 in GCF from healthy sites of Uyghur postmenopausal women; the increasing production of IL-6 may be associated with the intiation and progess of perodontitis. Il-6 may be a valuable indicator of the severity of periodontitis; E2 level is not associated with clinical measurements and GCF IL-6 level of chronic periodontitis Uyghuy woman in early menopause. E2 deficiency may be not a risk factor for postmenopausal Uyghur women with chronic periodontitis.