| Objectives: To study the function of Psychological factor of FD patientsby inspecting their anxious and depressive position; To study the clinicalsignificance of NPSR1, CGRP and IL-6of FD patients by testing theconcentration of these factors in their peripheral blood plasma.Methods：1. Choosed136FD patients who met the Rome III diagnosticcriteria in Gastroenterology clinic of Affiliated Hospital of North SichuanMedical College and divided them into two groups, PDS group with77patients and EPS group with59patients. At the same time, choosed40healthy people without FD or other diseases in Physical Examination Centerof Affiliated Hospital of North Sichuan Medical College as control group.2. Recorded the patients’ gender, age, weight, education background andtheir disease condition, etc. Compared the subtype of clinical date betweenFD patients group and the healthy control group and found out the difference.Recorded the related data for all the people by using SDS, SAS, FD symptomrating scale, somatization symptoms scale and life quality scale. Comparedthe anxious and depressive position between FD patients group and thehealthy control group and found out the difference. Compared the anxious anddepressive position between PDS and EPS group and found out the difference.Analyzed the relativity of anxious and depressive position between PDS andEPS group.3. Collected the peripheral blood sample of FD patients group andthe healthy control group. Tested the NPSR1, IL-6and CGRP concentration of the samples by ELISA. Compared the concentration between FD patientgroup and the healthy control group and found out the difference. Comparedthe concentration between PDS and EPS group. Analyzed the relativitybetween NPSR1, IL-6, CGRP and the patients’ anxious and depressiveposition.Results:1. The anxiety rates of FD group, PDS group, EPS group and the healthycontrol group were45.71±5.38,47.22±5.32,43.73±5.59,31.68±1.51.The anxiety rate of FD group, PDS group and EPS group was higher than thehealthy control group (p<0.01). The anxiety rate of PDS group was higherthan EPS group and the difference was significant (p<0.01).2. The depression rates of FD group, PDS group, EPS group and thehealthy control group were47.16±5.33,48.10±5.53,45.93±4.83,34.87±4.95. The depression rate of FD group, PDS group and EPS group was higherthan the healthy control group (p<0.01). The depression rate of PDS groupwas higher than EPS group and the difference was significant (p<0.01).3. The SAS and SDS rates among FD group patients were positiverelated (r=0.182, p=0.049). The SAS and SDS rates among PDS grouppatients were positive related (r=0.239, p=0.036). There was no obviousrelation between SAS and SDS rates among EPS group(r=–0.078, p=0.557).4. The concentration of fasting plasma NPSR1of FD group, PDS group,EPS group and the healthy control group was177.10±29.99,169.01±29.88,187.66±26.89,202.50±17.56. The concentration of FD group, PDS groupand EPS group was lower than the healthy control group (p<0.01). Theconcentration of PDS group was lower than the EPS group and the differencewas significant (p<0.01). The concentration of fasting plasma CGRP of FD group, PDS group, EPS group and the healthy control group was125.67±24.47,118.84±21.98,131.81±26.37,168.93±11.96. The concentration ofFD group, PDS group and EPS group was lower than the healthy controlgroup(p<0.01). The concentration of PDS group was lower than EPS groupand the difference was significant (p<0.01). The concen-tration of fastingplasma IL-6of FD group, PDS group, EPS group and the healthy controlgroup was90.16±5.87,87.47±5.47,93.67±4.32,68.33±4.48. Theconcentration of PDS group and EPS group was higher than the healthycontrol group (p<0.01). The concentration of PDS group was lower than EPSgroup and the difference was significant (p<0.01).5.The NPSR1and anxiety among FD group were negative related (r=–0.221, p=0.0097) and they were not obviously related to depression (r=–0.055, p=0.529). CGRP was not obviously related to anxiety (r=0.112,p=0.195) and depression (r=–0.102, p=0.237). IL-6was not obviously relatedto anxiety (r=–0.153, p=0.076) and depression (r=–0.126, p=0.145).6. The NPSR1and anxiety among PDS group were negative related (r=–0.252, p=0.027) and they were not obviously related to depression (r=0.064,p=0.579). CGRP was not obviously related to anxiety (r=–0.122, p=0.287)and depression (r=0.057, p=0.623). IL-6was not obviously related to anxiety(r=–0.09, p=0.435) and depression (r=–0.097, p=0.401).7. NPSR1was not obviously related to anxiety (r=0.015, p=0.912) anddepression (r=–0.084, p=0.529) among EPS group. CGRP was not obvio-usly related to anxiety (r=0.218, p=0.097) and depression (r=0.033, p=0.806).IL-6was not obviously related to anxiety (r=0.086, p=0.518) and depression(r=–0.027, p=0.84). 8. Among FD group, NPSR1and CGRP were not obviously related (r=–0.325, p=0.06); NPSR1and IL-6were positive related (r=0.313, p=0.000);CGRP and IL-6were not obviously related (r=–0.089, p=0.302). AmongPDS group, NPSR1and CGRP were positive related (r=0.652, p=0.000);NPSR1and IL-6were positive related (r=0.388, p=0.000); CGRP and IL-6were positive related (r=0.525, p=0.000). Among EPS group, NPSR1andCGRP were not obviously related (r=0.141, p=0.288); NPSR1and IL-6werenot obviously related (r=–0.01, p=0.939); CGRP and IL-6were not obviouslyrelated (r=–0.04, p=0.764).Conclusion:1. The study shows that FD patients have anxiety and depressioncondition. In FD group and PDS group anxiety and depression are positiverelated, which indicates psychological factors are highly related to FD. This isobvious in FD group and PDS group. Anxiety and depression may promoteFD. Therefore, it may improve the treatment and the life quality of FDpatients by treating their anxiety and depression with drug therapy andpsychotherapy comprehensively.2. The study shows the concentration of NPSR1and CGRP of FD group,PDS group and EPS group is lower than the healthy control group, and theconcentration of PDS group is lower than the EPS group. Among PDS groupNPSR1, CGRP and IL-6are positive related. All these results indicate thatNPSR1and CGRP are highly related to FD and this is obviously in PDSgroup. So we speculate that NPSR1and CGRP may be involved in theoccurrence of FD and NPSR1, CGRP, IL-6may play a synergistic role in thepathogenesis of PDS, aggravating the condition of PDS. However, the exact mechanism is not clear yet, which needs more research. NPSR1and CGRPmay become one of the indicators of assessing the condition of FD.3. The study shows that the concentration of IL-6of FD, PDS and EPSgroup is higher than the healthy control group, and the concentration of EPSgroup is higher than the PDS group, which indicates IL-6is involved in theoccurrence of FD. This is obvious in EPS group. So we speculate thatautoimmune inflammatory activation may play a role in the occurrence of FD.IL-6may be one of the indicators of assessing the condition of FD.4. In PDS group NPSR1and anxiety are negative related, whichindicates NPSR1may be involved in regulating anxiety. The anxiety of PDSpatients may affect the secretion of NPSR1. However, the exact mechanism isnot clear yet, which needs more research. |
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