Clinical Study On Treating Postoperative Fever After Cervical Cancer Surgery With Modified Mannose Disinfection Dan

Objeetive:Fever is a common postoperative complication after radicalhysterectomy and pelvic lymphadenectomy.A retrospective study on theincidence of febrile morbidity after radical hysterectomy and pelviclymphadenectomy for patients with early cervical cancers,found approximatelytwenty-five percent women had postoperative febrile morbidity. According tothe cause of postoperative fever,application antibiotics, antipyreticdrugs,physical therapy and other methods of treatment.Most patients can returnto normal temperature.Clinically,we often encounter some patients ofpostoperative fever，who used the above method of treatment,but persistentfever is quite tricky.We give these patients with traditional Chinesemedicine,which is modified mannose disinfection dan.Antipyretic effect issignificant.Mannose disinfection dan is ancient prescriptions on treating thedamp-heat syndrome.The pathogenesis of cervical cancer is inseparable thedamp-heat syndrome.Are postoperative fever related with damp-heat syndrome?Therefore,we investigate the clinical efficacy of modified mannose disinfectiondan in treating the patients with postoperative fever after Cervical cancersurgery,by observing the improvement of the temperature and clinicalsymptoms of pre-treatment and post-treatment and detecting the content of IL-1in serum in this stuy.Methods:This study observe362cases of patients undergoing radicalhysterectomy and pelvic lymphadenectomy at Fourth Hospital of HebeiMedical University since December2012to December2013,of which50casesmet the inclusion criteria.These cases are divided into two groups byusing random contrast clinical research methods.The treatment group and thecontrol group are respectivly25patients. The treatment group had been treatedwith imipenem and mannose disinfection dan,and the control group had been treated with imipenem.A course of treatment is5days.To observe and comparethe clinical efficacy of the two groups.Gathering blood from two groups and25heathy people as normal comparative group.The blood were drawn from thecubital vein, and isolated serum.These serum adopt ELISA to detect the contentof IL-1in the serum.All information using SPSS13.0statisticalanalysis.Measurement data is expressed as" X±S"or"M(QR)",if obey thenormality and homogeneity of variance,measurement data use T-test,if do notobey the normality and homogeneity of variance,using rank sum test.Level datause Wilcoxon test.Count data is expressed in frequency,and use X2-Test. P＜0.05was considered statistically significant.Result:(1)It is shown that the two groups can obviously improve cilinicalsyndrome of postoperative fever with pattern of damp-heat brewing aftercervical cancer surgery.The effective rate of efficacy of disease is92.0%in thetreatment group,the control group is80％.There were statistics differencesbetween the two groups(P<0.05).The treatment group is better than the controlgroup.(2)It is shown that the average antipyretic effect beginning time in thetreatment group is4.50±0.84hours,the control group is5.28±0.89hours.There were statistics differences between the two groups(P<0.05).Theaverage antipyretic effete beginning time in the treatment group is shorter thanthe control group. The two groups had a good effect on treating postoperativefever. It is showed that the temperature is gradually declining trend between thetwo groups on post-treatment.There were statisties differences between the twogroups from the third day,The P value are respectivly0.040,0.000,0.044(Both<0.05).There was statistically significant.It is indicatedthat the efficacy of the treatment group is better than the control group.(3)Thecontent of IL-1between the treatment and control groups are higher than thenormal group in pre-treatment.The three groups are respectivly(95.94±6.54)pg/ml,(95.96±9.04)pg/ml,(80.28±10.09)pg/ml,there were statistiesdifferences(P<0.05).The content of IL-1compare the treatment group with thecontrol group in pre-treatment(P＞0.05).There was no statistically significant.It is indicated that the two groups were comparable.Comparison of pre-treatment and post-treatment in the treatment group(P＜0.05).There wasstatistically significant.It is indicated that mannose disinfection dan can reducethe content of IL-1in serum.Comparison of pre-treatment and post-treatment inthe control group(P＜0.05).There was statistically significant.It is indicatedthat imipenem can reduce the content of IL-1in serum.The content of IL-1arerespectivly (82.22±8.14)pg/ml,(81.02±10.26)pg/ml,(80.28±10.09)pg/mlamong the treatment group.Comparison of the three groups, there were nostatisties differences(P＞0.05). The two groups can obviously reduce the levelof IL-1.Comparison of the treatment group and the control group inpost-treatment,there were no statisties differences between the two groups(P＞0.05).Conelusions:The clinical efficiency is curative on treating postoperativefever after cervical cancer surgery with mannose disinfection Dan.It cansignificantly improve pations with fever,chills,abdominal distention,nausea andother symptoms and signs.With the rapid onset,good cooling effect,stableefficacy,fewer side effects,it is worthy of clinical application.It can reduce thecontent of IL-1in serum.Postoperative fever after cervical cancer surgerybelong to damp-heat syndrome.