The Multi-center Clinical Study Of Integrated Program Of Traditional Chinese Medicine Treatment On Osteoarthritis Of The Knee

Objective:To verify the clinical effects and the feasibility of applying in basic level of curing knee osteoarthritis(OA) using electro-acupuncture, om package of Chinese medicine combined with rehabilitation exercise, and to normalize and detailing every step of operation and technical parameters simultaneously. So as to achieve the purpose for repeating and extending application, and develop the advantages of curing the knee OA with traditional Chinese medicine.Method:According the diagnostic and inclusive criteria, there were198cases with knee osteoarthritis included in this clinical trial. A multicentral, random and controlled method was used,we devided198patients into two groups and they were given different treatments respectively. Ninety-nine patients in treatment group were given electro-acupuncture, om package of Chinese medicine combined with rehabilitation exercise once a day for continuous5days a week as a course of treatment. Then they were arraged to take a rest for the surplus2days in a week and they should do rehabilitation exercise by themselves, they were given3courses of treatment, that was3weeks in all. The other99patients in control group were given diclofenac sodium spansule50mg twice a day for three weeks(diclofenac sodium spansule was produced by Nanjing Chang ao pharmaceutical Co. Ltd,24capsules in a box). We assessed each patients using the WOMAC, knee joint symptoms score and psychological and social adjustment scale at each time point:before treatment, one week after treatment, two week after treatment, and the end of treatment. Results:1. Eectro-acupuncture, om package of Chinese medicine combined with rehabilitation exercise,the treatment of osteoarthritis of the knee compared with oral diclofenac sodium sustained-release capsules, the treatment group was96%, the control group was92%, the treatment of the two groups were statistically, the curative effect in the treatment group was superior to the control group.2.By the Man-Whitney U test, the indicators in both the treatment group and control group have significant differences before and after treatment (P<0.05), which illustrate that the treatment in two groups both have obvious effects for improving knee osteoarthritis indicators. Between the two groups were compared by the Man-Whitney U test(p<0.05), there was a obviously different for relief of pain, daily activities and signs between the two treatment groups. The treatment group on the felief of pain, daily activities and signs were better than the control group. But there was no significant difference for the ease of rigidity and psychological between the two groups(P>0.05).3. In the treatment group, the incidence of adverse reactions was1%, in the control group, the incidence of adverse reactions was18%, and poor treatment group was significantly lower than the control group.Conclusion:1.The curative effect of electro-acupuncture, om package of Chinese medicine combined with rehabilitation exercise treatment for knee joint osseous arthritis is better than that of oral diclofenac sodium capsules.2. Electro-acupuncture, om package of Chinese medicine combined with rehabilitation exercise treatment is much better than oral diclofenac sodium capsules for relieving knee joint pain, daily activities, and body signs for patients with knee OA.The two treatment methods can both improve patients with knee joint rigidity and psychological and social adaptation ability, but there is no significant difference between them. 3.The treatment of knee OA using electro-acupuncture, om package of Chinese medicine combined with rehabilitation exercise was significantly lower than the control group, simple for operation,easy to follow and is worth of extending.