The Study Of The Mechanism Of The Antidepressant Effect Of Tianjingyiqiyangxuefa

Theoretical researchDepression is a nonaggressive modern medicine，Western medicine textbooks and didnot give a clear definition of its concept，is In mood disorders in the depressive episode. Theclinical manifestations include a variety of complex physical and mental changes，in whichsignificant and long depression as the main feature. Chinese medicine and depression-relateddiseases have been documented for thousands of years despite a history of clinicalmanifestations of disease or the core symptoms of depression and depression similar or othersymptoms are similar but different place. Therefore，from the Chinese point of depression，can not stand alone from a disease similar to TCM theory of governance， in conjunction withclinical realities and modern medical diagnosis of depression，considering the diagnosis andtreatment. Through the study of depression to further clarify the meaning of our object ofstudy.About the pathogenesis of depression，doctors so far still no clear，still stuck in thehypothesis basis. Currently on the pathogenesis of depression hypothesis proposed are:monoamine neurotransmitter function lacking； neuroendocrine system abnormalities；brain-derived neurotrophic factor(BDNF)in the cortex and hippocampus lacking；hypothalamic-pituitary-adrenal cortex (HPA) axis hyperactivity and the consequent effectof a series of follow-up；inflammatory response theory；combined effects of multiple factors，of which the first three hypotheses of the study is more mature. The first three hypotheses andby analyzing the correlation between depression，we can conclude: mutual influence betweenthe various hypotheses，interactions indivisible whole point of view. The human body is amulti-system unified whole，and between each of the systems within the system is theinteraction between the various elements of the complex interaction of unity，there is noindependent hypothesis，no elements are not associated. Are the result of a variety ofhypotheses but also because they are related to each other between. With further research，science and technology，mankind will propose additional hypotheses，the final integration ofmany hypotheses will be a whole spectrum of the same genes as humans are linked togetherto form a variety of relationships between complex and closely linked to the there regularity indivisible whole. This is in Chinese medicine，"overall view" was in line. From the Chinesewith depression-related diseases Pathogenesis of view，are：ganqiyujie， xinpiliangxu，ganyupixu，ganshenbuzu，yinxuhuowang，etc. Pathogenesis in the corresponding classicaltheory of compound chosen under the guidance and in accordance with specific conditions forpatients Clinical subtraction used to treat depression，and achieved good clinical efficacy.TCM pathogenesis of depression’s view，has been most physicians agree that the "yiganlunyu"point of view，more than that，"ganyuqizhi" is the main pathogenesis of depression. But inrecent years，TCM pathogenesis of depression development trend，the "zangfuxusun" as thepathogenesis of depression research more and more，and in the diagnosis and treatment underthe guidance of the disease machine using the corresponding organs of the Chinese toniccompound experimental and clinical treatment studies have achieved some results. And fromtraditional Chinese medicine and depression-related diseases pathogenesis of view，wuzangxusun is also part of the pathogenesis. So wuzangxusun as one of the pathogenesis ofdepression is evidence-based. In recent years through the collation and analysis of relevantexperimental and clinical studies have found: These experimental and clinical studies morefrom one or two organs of the deficiency theory of governance，such as ganyupixu，xinpiliangxu，ganshenbuzu，etc. I tutor in clinical practice，summed up: Many patients withdepression in the disease process in its pathogenesis is not one，two organs of the lossescaused by virtual Instead，the internal organs are connected，can cause false. Combined withthe "neijing"，"wushenzang" theory we have come: impassioned tone，inevitably damageinternal organs，damage to internal organs can not be fine，fine gas leakage can not be closed，then the loss of the support of God’s people o utside behavioral activity disorders，can seeactions and thinking abnormal changes，such as frequent insomnia，sleep will be chaos dreamwas divided，when issued delirium，restless mind often horrified，looked sluggish and so on.So we put forward the "wangzangjingkui，jingbuyangshen" is one of the pathogenesis ofdepression.Current Western medicine treatment of major depression is medication.Antidepressant drugs on the market and a lot of new drugs emerging，through the analysis ofits mechanism of action of drugs，mostly: by blocking or exogenous activator make anexception occurs in vivo in patients with depression indicators returned to normal range and reach of antidepressant treatment effect. Mechanism of action of antidepressant drugs inblocking the "path" to make an exception in vivo in patients with depression indicatorsreturned to normal. But it also can not be ruled out that these "path" is also a normalphysiological path. In addition，these materials may also exist in other parts of the humanbody in another form of play different physiological role. This medicine may be in itsantidepressant inevitably occur during treatment of side effects and adverse reactions.Currently TCM treatments for depression are mainly Chinese compound treatment. Chinesemedicine is in a different pathogenesis medicine under the guidance of the correspondingcompound used for treatment，but Chinese medicine in the clinical treatment of compound butnot rigidly adhere to a specific combination of multiple subtraction with the disease inpatients with specific conditions applied flexibly，overall conditioning，so that the body itselfto achieve a best condition to resist disease and achieve antidepressant effect. Meanwhilemedicine in the treatment effective measurement range so far not been found adversereactions and side effects. According to our "wuzangjingkui，jingbuyangshen" theory ofpathogenesis founded the"tianjingyiqiyangxue"method of treatment. For the " wuzangjingkui，jingbuyangshen " in the pathogenesis of characteristics，rational drug use election party，founded a prescription "jieyukaixindan."The disease is now further proof machine，inquiry"tianjingyiqiyangxuefa" antidepressanteffect the pathogenesis of depression and modern relevance. Years of experience in the use ofmentors party "jieyukaixindan" as the control drug，combined with the Western theory. Usemore modern research， monoamine neurotransmitter theory；neuroendocrine abnormalities；brain-derived neurotrophic factor expression abnormalities of these modern pathogenesis ofdepression research indicators as a research object，using animal testing methods. Analysis ofexperimental results further confirmed that "wuzangjingkui， jingbuyangshen" for thepathogenesis of major depression，which explore the "tianjingyiqiyangxue" and the modernantidepressant effect of depression correlation between pathogenesis.Experimental studyPurpose: To observe the affect to depression in rats model that treated by Jieyukaixindanwhich is created by Tianjingyiqiyangxue method. To explore Tianjingyiqiyangxue method’santidepressant mechanism， and to explain the correlation between Wuzangjingkui， Jinbuyangshen pathogenesis and the generation of the depression.Method:80SD rats in free diet，natural light，and adaptive feeding for one week. Makethe behavioral score by Open-Field scoring method. Exclude the rats who’s score is≥120or≤30，the last rats are randomly divided into six groups.10in normal control group，10inmodel group，10in Fluoxetine group，10in Chinese medicine high dose group，10in Chinesemedicine middle dose group，and10in Chinese medicine low dose group，the last5groupswas treated by water deprivation for24h，fasted for24h，4℃ice water swimming5min，2h behavior restrictions，tail clamp1min，humid environment， day and night reversed，and the rat was in different stress factors every day which is randomly decided. After3weeks’continuous stimulation，the depression model was made，normal control group were nottreated. Intragastric administration was given after the completion of the modeling，positivecontrol group was given fluoxetine hydrochloride suspension10mg/kg/d，positive controldrug’s high， middle and low dose group were givenJieyukaixindan2.0g/kg/d，1.0g/kg/d，0.5g/kg/d (Given1.0mL dose volume per100g body weight). Model control group were givennormal saline. Get blood and brain tissue of rats in each group after4weeks，detecting thecontent of Brain5-HT，DA，NA；Serum cortisol and serum-endorphin’s content； Theexpression in SDNF hippocampus and habenula nucleus.Result: The content of brain5-HT，DA，NA，serum cortisol and serum-endorphin andthe expression in SDNF hippocampus and habenula nucleus all showed significant differencein the blank with the model group (P<0.05)，model group，Chinese medicine high dose group，Chinese medicine dose group，fluoxetine group were significantly different (P <0.05)；modelgroup and Chinese medicine low dose group was no significant difference (P <0.05).Conclusion:Experimental results show that tianjingyiqiyangxuefa founded the"jieyukaixindan" has the same medicine the same antidepressant effect of fluoxetine， infer"tianjingyiqiyangxuefa" by tianjingyiqiyangxue， shuganjieyu， zhenjinganshen effect， thuscomplementing the body’s blood， the body’s overall reconcile qiji， yinyang effect achievedwith the same medicine antidepressant treatment outcome， which reflects the overall conceptof the advantages of traditional Chinese medicine. At the same time an effective measure intheir treatment so far has not been found within the scope of adverse reactions and sideeffects.