The Clinical Study Of Jianpibushenhuashijiedu Decotion With L-OHP+S-1Chemotherapy In The Treatment Of Patients With Advanced Colorectal Tumor

Objective:The study JianPiBuShenHuaShiJieDu Decotion combined with L-OHP+S-1Chemotherapy on the clinical efficacy of advanced colorectal cancer, to further clarify the therapeutic effect of JianPiBuShenHuaShiJieDu Decotion.Methods:40cases of colorectal cancer patients were randomly divided into a treatment group and a control group.20cases in which the treatment group, taking the side of the spleen kidney dampness detoxification, a daily, and even served six weeks, and L-OHP+S-1chemotherapy.20cases of the control group, simply to L-OHP+S-1chemotherapy. Groups before and after treatment, and the two groups after treatment efficacy evaluation after two cycles.Results:TCM symptom comparison:treatment group was significantly higher efficiency, and the treatment group, the effective number than the control group, statistical tests, P=0.013<0.05, the difference was statistically significant. Improve the quality of life:After treatment QOL score and Karnofsky By comparison, the difference was statistically significant (P <0.05).Weight:the weight gain of the treatment group12cases, the stability of six cases, the decline in the two cases;4cases in the control group, weight gain, stable for seven cases, decreased for the nine cases, by the chi-square test Both groups had a significant difference (P=0.014<0.05). But this study tumor the recent objective response and reduction of serum tumor marker failed to show a significant advantage (P>0.05). Evaluation of toxicity:treatment group in hemoglobin decreased, thrombocytopenia, decrease in serum transaminases, creatinine reduce the incidence of diarrhea compared with the control group, but there was no statistical difference (P>0.05). Two groups in leukopenia, nausea and vomiting difference was statistically significant (P<0.05).Conclusion:JianPiBuShenHuaShiJieDu Decotion combined L-OHP+S-1Chemotherapy to improve the clinical symptoms of patients with advanced colorectal cancer and improve the quality of life, reduce chemotherapy toxicity, there is a definite role in stabilizing the tumor and reduce tumor marker showing no advantage. JianPiBuShenHuaShiJieDu Decotion is one of the effective methods for the treatment of colorectal cancer.