| Backgroud:Allergic rhinitis, body contact allergen, IgE-mediated, non-infectious inflammatory disease in the nasal mucosa, nasal congestion, nasal itching, runny nosetears, sneezing main symptoms of the disease. Modern medical treatment is generally taken to avoid contact with allergens, drug therapy, immunotherapy and surgical therapy. The medication is clinical easiest and most commonly used method, the main use of antihistamines and glucocorticoids block the allergic reaction, but there are short-lasting effects of drugs, obvious side effects.Day moxibustion, also known as foam moxibustion, belonging to external treatment of traditional Chinese medicine, some skin irritant drugs sticking points or parts of the skin cause local skin congestion, foam, or even purulentlike moxibustion sore, so as to achieve the purpose of treatment of disease. Divided into the dog days moxibustion and thirty-nine days moxibustion two treatment under different solar terms, because both disease treatment, disease prevention before cure characteristics, application to ancient physicians respected.Our previous animal studies fully affirmed days moxibustion treatment of the efficacy of AR, the test further days moxibustion therapy the AR clinical application, verify its clinical efficacy observed clinical manifestations and improved quality of life. Additionally, the majority of dog day moxibustion treatment time limited in the dog days of summer, a result acupoint sticking clinical application is limited. Therefore, the research on non-dog days, non-thirty-nine days ordinary Acupoint Application AR is also very necessary.Object:Topics, days moxibustion treatment of AR clinical research, to be from the patching drugs and sticking two angles to verify moxibustion days validity, it is designed dog day moxibustion and the dog days of sticking a blank drug control, dog day moxibustionand non-dog days acupoint sticking (acupoint application) control the two research programs; For non-dog days, the ordinary points thirty-nine days sticking therapy AR looking for evidence of the feasibility of the time of year to carry outto provide ideas and selected on the basis of acupoint sticking therapy for AR.Method:1. Dog day moxibustion with the dog days of sticking a blank drug groupGrouping:met the inclusion and exclusion criteria60AR patients, in accordance with the randomization number of incoming packets, with30cases in each group, were named according to the different treatment options the dog day moxibustion group and the placebo group (the dog days of sticking a blank drugs).During the test:dog day moxibustion group selection of of Doctor Chang Babel moxibustion side, Corydalis, Mustard Seed, Asarum, euphorbia research into the fine mixed spare a ratio of2:2:1:1, fresh ginger juice stand. To Ojo, throttle (double), Feishu (double), spleen (double), Shen Shu (double) the main points acupoint sticking therapy, each selected6-7points. If Feishu, shenshu damaged at reelection Gaohuangshu Chi room, to choose the rotation of the main points. The treatment time was during the dog days of summer2010.10days paste,5times for one course of treatment.The placebo group were buckwheat flour, fresh ginger juice stand. Acupoints, treatment time, the same operation with the dog day moxibustion group.outcome measures:All patients before treatment, the last1acupoint application (hereafter referred to treatment) and after six months follow-up, three indicators assessed clinical outcomes included:(1) Clinical efficacy:Reference1997Chinese Medical Association China ENT credits will be amended by the Committee of "Chinese Journal of Otorhinolaryngology" Edit "AR diagnostic criteria and efficacy assessment standards efficacy evaluation sub-clinical evaluation standard.(1) clinical symptoms scoring criteria, according to the1997Chinese Medical Association Chinese ENT credits will be revised the AR diagnostic criteria and evaluation standard efficacy evaluation sub-clinical symptoms classification scoring criteria;(2) clinical signs classification scoring criteria, according to the1997China Medical Association China ENT credits will be revised AR diagnostic criteria and evaluation standard efficacy evaluation clinical signs points classification scoring criteria, and then self-rated;(3) based on the sum of the before and after treatment of the signs and symptoms score, the percentage of improvement below assessed the efficacy of AR formula:(pre-treatment score-after treatment score)/treatment before the total score×100%.≥51%as effective,50%to21%,≤20%as invalid.(2) the improvement of the clinical manifestations of:(1) improvement of clinical symptoms, the same symptoms in the clinical efficacy of the the classification scoring criteria;(2) clinical signs improve the situation, with the clinical efficacy signs classification scoring criteria;(3) the overall improvement of the clinical manifestationsby the sum of the clinical symptom score and symptoms score made.(3) the improvement of quality of life:using quality of life scale (RQLQ) Assessment of quality of life before and after the treatment of patients with AR, the scale include nasal symptoms, eye symptoms, nose and eyes symptoms, sleep disorders, behavioral problems, and activities restrictions and affective disorder factor scores and the total score of the seven aspects change.Data processing:all the data by hand finishing. The data obtained using the SPSS13.0statistical package for statistical analysis.2. Dog day moxibustion and non-dog days acupoint sticking controlGrouping:60AR patients meet the inclusion and exclusion criteria, number of incoming packets according to the randomization,30patients per group, named the dog day moxibustion group and acupoint application group (non-dog days points paste according to the different treatment time, respectively,apply).Testing process:the two groups are selected the Doctor Chang Babel moxibustion side, the same as the "clinical research" during the test.Treatment time dog day moxibustion group in2010during the dog day moxibustion (time:20109July sun volts strengthened July2010the19sun volts, July29,2010ambush, August8,2010Mofu August18,2010Mofu strengthened). Ordinary acupoint application group in2010non-dog days, non-three-nine days during the period (time:June1,2010, June11,2010, June21,2010, July1,2010, and2010July11,2009).outcome measures:The outcome measures with the "clinical research". Data processing:with the "clinical research" data processing."Result:1. Dog day moxibustion with the dog days of sticking a blank drug group (1) Two groups of gender, age, duration no significant difference (P<0.05), comparable.(2) Clinical efficacy:the clinical efficacy of the two groups of patients there was a significant difference (Z=-2.767, P=0.006).(3) Clinical manifestations:①Clinical symptoms:compared with before treatment, dog day moxibustion group patients with nasal itching, sneezing and nasal symptoms score in the treatment and follow-up scores were significantly lower (P<0.05), and symptoms of runny scores was not statistically significant (P>0.05), while the placebo group of indicators showed no significant difference (P>0.05); Dog day moxibustion group compared with placebo, in the treatment of nasal itching, nasal congestion, runny clear nasal discharge, sneezing symptom score decreased (P<0.01-0.05).②Clinical signs:compared with before treatment the dog day moxibustion group turbinate of patients with nasal, eye signs and color of the nasal mucosa, and placebo eye signs after treatment and follow-up scores were lower (P<0.05); compared to placebo the dog day moxibustion group patients after treatment and follow-up turbinate and nasal mucosa, nasal color score decreased (P<0.05), eye signs were no differences (P>0.05).③overall clinical manifestations:compared with before treatment, the dog day moxibustion group symptom score, signs score and clinical manifestations total score after treatment and follow-up scores were lower (P<0.05), while the placebo group compared significant difference (P>0.05); compared with placebo, dog day moxibustion group symptom score, signs out of the total score of clinical manifestations in the treatment and follow-up scores decreased (P<0.05).(4) quality of life:compared with before treatment, dog day moxibustion group behavioral problems, nasal symptoms, emotional response, and quality of life scores after treatment and follow-up scores decreased (P<0.05) in the placebo group daily life, behavioral problems and quality of life score after treatment and follow-up scores decreased (P<0.05); compared with the placebo group, dog day moxibustion group nasal symptoms, emotional reactions and overall quality of life after treatment and follow-up time divisionvalue decreased (P<0.05), non-nose/eye symptoms, behavioral problems, daily life only in the follow-up score decreased (P<0.05).2. Dog day moxibustion and non-dog days acupoint sticking control(1) Two groups of gender, age, duration no significant difference (P<0.05).(2) Clinical efficacy:the clinical efficacy of the two groups of patients showed no significant difference (Z=-0.846, P=0.398).(3) Clinical manifestations:①Clinical symptoms:compared with before treatment, the two groups of patients with nasal itching, sneezing, runny and stuffy nose symptom score after treatment and follow-up were lower (P<0.05); ordinary acupoint sticking group, the dog day moxibustion group of patients runny symptom score decreased in the six months after the follow-up is greater than ordinary acupoint application group (P <0.01), the remaining symptom score was no significant difference (P>0.05).②Clinical signs:compared with before treatment, signs of scores of each of the two groups after treatment and follow-up were lower (P<0.05); compared with ordinary acupoint application group, the two groups of patients and signs score was not statistically difference (P>0.05).③overall clinical manifestations:compared with before treatment, the two groups were symptom score, signs of the total score and clinical manifestations Total score after treatment and follow-up were lower (P<0.05); ordinary acupoint sticking group, out of scores of the total score of the two sets of symptoms, signs of the total score and clinical manifestations was no significant difference (P>0.05).(4) quality of life:compared with before treatment, the two groups of patients with behavioral problems, the nasal symptoms factor, emotional response, and the quality of life score score after treatment and follow-up were lower (P<0.01); common acupoint application group compared to patients, the dog day patients in addition to the non-nasal eye symptoms, quality of life score scores after treatment and follow-up, a large decrease (P<0.01-0.05), eye symptoms, emotional response scores decline at follow-up (P<0.01-0.05), and the rest of the quality of life scores were not statistically different (P>0.05).Conclusion:1.with the placebo group compared the clinical efficacy of the dog day moxibustion group is exact, can be used to improve the clinical symptoms and the clinical signs and sustainable to six months follow-up, sustainable significantly improved the quality of life of patients, it is in clinicalpromote the application.2.with dog day moxibustion contrast, the common point sticking with similar clinical efficacy, almost similar to ordinary acupoint application and dog day moxibustion clinical efficacy, clinical symptoms and signs, as well as improvement in quality of life, in the dog days moxibustion, including the acute phase of the disease, promoting days moxibustion side.3.of this thesis there are still some shortcomings:First, ordinary acupoint application selected with a dog moxibustion select a time too close; Second, the small sample size, short follow-up time. |
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