The Cognitive Function And Cognitive Patterns Of Depression With Childhood Trauma

Objective:1) To explorer the impact of childhood trauma and depression on Neurocognitive function.2) To investigate the relationship between childhood trauma and cognitive biases.Methods:Patients of major depression and the healthy adults were assessed by Childhood Trauma Questionnaire (CTQ). Then the patients were divided into the depression group with childhood trauma and without childhood trauma, as well as the healthy adults were divided into the control group with childhood trauma and without childhood trauma. All subjects were administrated for cognitive function with neuropsychological tests:the Stroop color word Test, Trail Making Test, Wisconsin Card Sorting Test, Verbal fluency test, and Wechsler Memory scale et al. All subjects also were assessed for cogntive biases with Dysfunctional Attitudes Scales (DAS) and The Cognitive Bias Questionnaire (CBQ).Results:1) The main effect of depression diagnosis existed in the Trail Making Test, the Stroop color word test, WCST, Verbal fluency test, and associated learning, visual reproduction and understanding memory in WMS.2) The main effects of childhood trauma were found in the words of the Stroop color word test subtests, WCST, verbal fluency test and visual reproduction test in WMS.3) In The number of persistent errors in WCST and verbal fluency test, the interaction of depression and childhood trauma was found, and the control group without childhood trauma had a significant difference with the other three groups.4) In the groups with childhood trauma, including the depression group with childhood trauma and the control group with childhood trauma) there was no significant correlation between cognitive impairment and the five forms of childhood trauma score.5) The cognitive biases questionnaire depression-distorted score and the five structure factor scores of the dysfunctional attitude, which including vulnerability, attraction and repulsion, approval, dependency and cognitive philosophy, were higher in the control group with childhood trauma compared to the control group without childhood trauma.(P<0.05).6) Related analysis showed that the total score of DAS and the score of depression-distort, were significantly associated with the total score of CTQ. Multiple regression analysis showed that emotional abuse was a significant predictor of dysfunctional attitudes, while physical neglect was a significant predictor of depression-distortion.Conclusion:1) Regardless of childhood trauma, depressive patients presented general cognitive domains impairment including information processing speed, executive function, working and short-term memory. The adults with childhood trauma performed cognitive impairment in executive and memory function.2) Depression overlaped childhood trauma in damages to cognitive function. The two factors of childhood trauma and depression both affected in cognitive functions including persistent errors of the executive function and working memory.3) The dose-response relationship between cognitive dysfunction in adults with childhood trauma and different forms of childhood trauma may do not exist.4) There were more cognitive biases in healthy adults with childhood trauma than healthy people without childhood trauma. The more severe the degree of childhood trauma, the more significant cognitive biases, and in which emotional abuse and physical neglect played the most significant effect in negative cognitive bias of healthy adults.(2pictures,16tables,83references)...