Effects Of Cognitive Impairment On The Clinical Outcomes In Patients With Major Depressive Disorder

Objective: Effects of cognitive impairment on the clinical outcomes in patients with major depressive disorderMethods: Patients with major depressive disorder and healthy control group were selected as subjects.The Hamilton Depression Scale and the Simplified International Neuropsychiatric Interview were used to evaluate the clinical symptoms of the patients.Including: Animal Fluency Test(AFT),Color Trails Test I(CTT1),Symbol Code Subtest(SC),Stroop Color Word Test(SCWT),Hopkins Verbal Learning Test Revised,(HVLT-R),Brief Visuospatial Memory Test-revised(BVMT-R),Pair of Major Depressive Disorders and Normal The control group underwent cognitive function assessment;the HAMD factor scores and the baseline neuropsychological test were compared between the depressive disorder shedding during the follow-up(not completed8 weeks follow-up assessment)and the completed treatment(completed 8-week follow-up assessment);The 8-week survey was conducted for the depressive disorder subjects,neuropsychological tests and HAMD assessments were performed at baseline,and HAMD was evaluated at the 8th week.In addition,subjects with depressive disorder who completed 8 weeks of treatment were grouped according to the HAMD score at Week 8: clinically cured group(HAMD ≤ 7),clinical untreated group(HAMD > 7),compared to baseline neuropsychological test To explore the impact of cognitive impairment and clinical outcomes in patients with depressive disorder.Result: 1.In the information processing of depression group: SC(P=0.025),SCWT words,SCWT color,SCWT color word score(P<0.05)were significantly lower than the control group;words learning and memory: depression group in HVLT-R The scores of the total number of recalls and delayed recalls(P<0.05)were lower than those of the control group;the visual learning/memory: BVMT-R total score(P=0.003)and delayed score(P=0.004)were significantly lower than the control group;Attention/alertness:CPT-IP 2 digits,3 digits,4 digits,and mean scores in the depression group were lower than the control group(P<0.05).The HAMD scores in the baseline group of the shedding group were not statistically significant compared with the completed group.Psychological tests were compared that the BVMT-total score(P=0.035)was lower than completion group and was statistically significant.3.Comparison of the baseline psychological neuropsychological test between the clinical cure group and the clinical untreated group: AFT(P=0.001)and CTT1 score(P=0.018)in the clinical untreated were significantly lower than those in the clinical cure form.Correlation analysis between the of HAMD score and neuropsychological test in the depression group showed that HAMD score was negatively correlated with the neuropsychological test score.Conclusion: 1.Patients with better cognitive function in depressed patients have better clinical curative effect and higher clinical cure rate.2,the degree of cognitive impairment of patients with shedding is heavier.3.The more severe the depressive symptoms of patients with depressive disorder,the more obvious the damage of cognitive level.