| Objective: Cervical cancer is one of the common gynecologic malignant tumors,serious harm to the health of the women. In recent years, the pathogenesis of cervicalcancer shows the trend of the young, after these patients undergoing comprehensivetreatment (surgery and/or chemotherapy).After Ovariectomy or combined treatmentovarian function reduced,obvious menopausal syndrome and the body which cause aseries of changes, such as the change of the blood, bone loss, heart cerebrovasculardisease incidence rate rise, sexual dysfunction, which seriously affected the patients’quality of life after cancer cure. Hormone Replacement Therapy (HRT) is a kind ofeffective method, that is add appropriate amount of hormones to relieve patients’menopausal symptoms, and to improve the level of hormone to reduce the aboveproblems. However, doctors and patients pay attention to the effect of HRT, at the sametime, worry more about the use of HRT will promote cancer metastasis and recurrence.Squamous cell carcinoma antigen (SCC-Ag) is specific maker of cervical squamouscarcinoma, widely used in the disease condition assessment, curative effect andrecurrence monitoring, etc. The experiment was designed to study the efficacy ofcervical cancer and how much estrogen in the postoperative patients including serumfollicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), totalcholesterol (TC), high-density lipoprotein (HDL), low density lipoprotein (LDL), totalalkaline phosphatase (ALP), squamous cell carcinoma antigen (SCC-Ag). And we candiscuss the clinical value of estrogen after surgery on cervical cancer patients.Method:We selected patients from January2009to2012July diagnosed withcervical squamous cell carcinoma and underwent surgery in Beijing Military GeneralHospital. We divided them into two groups, excision of bilateral annex and bilateralannex not removed.44patients appeared menopausal symptoms after surgery but all ofthem did not have any menopause.28patients in the test group voluntarily acceptedestrogen and16patients in the control group used nothing. With radioimmunoassay for the detection of patients blood follicle-stimulatinghormone (FSH), luteinizing hormone (LH), estradiol (E2) content and by thebiochemical instrument for the detection of patients serum total cholesterol (TC), highdensity lipoprotein (HDL), low density lipoprotein (LDL).On the method offluorescence spectrometry detection to observe two groups`total serum alkalinephosphatase content before adding drugs and after adding drugs six months and toevaluate the influence of single estrogen addition on the sex hormone levels and theblood lipid levels. Use the improved Kupperman scoring method to evaluate theimprovement of menopausal symptoms.Statistical analysis was finished by the SPSS13.0. Test for normality. If meet thenormality, choose the t-test. If not, choose Mann-Whitney U test. P<0.05was acceptedas statistically significant.Results:1The difference of Kupperman score between before and after the additionBefore addition, the experimental group patients’ kupperman score is20.52±7.60.After addition for6months, the experimental group patients’ kupperman score is11.52±5.06.THE score have decreased obviously than before addition. The differencehas statistical significance (P<0.05). There are no obvious changes of the control grouppatients’ kupperman score (P>0.05).2The difference of content of E2, FSH, LH between before and after the additionBefore addition, the experimental group patients’ content of E2, FSH, LHrespectively is13.99±5.86、62.39±19.32and35.19±6.62， After addition for6months,the content of E2, FSH, LH respectively is39.89±7.82、34.39±7.64and20.33±6.31. E2has increased significantly than before addition. FSH and LH have decreased obviouslythan before addition. In the control group, E2has slightly decreased than before, FSHand LH has slightly increased than before. But there are no significant statisticaldifferences (P>0.05).3The difference of content of TC, HDL, LDL between before and after theadditionBefore addition, the experimental group patients’ content of TC, HDL, LDLrespectively is4.33±0.88、1.32±0.23、2.99±0.80， After addition for6months, thecontent of TC, HDL, LDL respectively is4.01±0.49、1.63±0.31、2.79±0.44， HDL hasincreased significantly than before addition. TC and LDL have decreased obviously thanbefore addition. The differences have statistical significance (P<0.05).There are no obvious changes of the control group patients’ content of TC, HDL, LDL (P>0.05).4ALP in blood changes before treatment after treatmentThe normality test concerned ALP meet normality so we used independent samplet-test. serum ALP values were46.96±9.16and66.13±25.93before treatment. ALPdifferences were statistically significant (P <0.05) compared with result which is beforetreatment.5The content of serum SCC-Ag groups before and after addition six monthsBefore addition, the experimental group patients’ content of serum SCC-Agwas0.91±0.40, the control group was0.98±0.32.After addition six months, theexperimental group patients’ content of serum SCC-Ag was0.83±0.32the control groupwas0.88±0.28. There is no statistical difference between the two groups(P>0.05).Results showed that the addition of estrogen did not cause the rise ofSCC-Ag.Combined with clinical examination and relevant auxiliary examination, thereare no relapse cases and abnormal changes of breast in the two groups.Conclusion:1After combined treatment of cervical squamous cell carcinoma patients caneffectively reduce the level of patients’ FSH and LH, increase the content of E2, hasobvious improvement effect on menopausal syndrome. It is very good to improve thepatients’ quality of life.2After combined treatment of cervical squamous cell carcinoma patients caneffectively reduce the content of patients’ serum TC and LDL; increase the content ofHDL; improve the content of total serum alkaline phosphatase.Because it can improvethe postmenopausal women’s biochemical indicators, it has a good preventive action oncardiovascular and Osteoporosis.3After comprehensive treatment of cervical squamous cell carcinoma, patientsusing estrogen after a short period of time does not affect the rate of recurrence ofcervical squamous cell carcinoma. |
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