Expression And Application Of The Serum Squamous Cell Carcinoma Antigen In The Infiltrating Cervical Cancer

Objective:To determine the prognostic significance of the pre- and posttreatment serum levels of the squamous cell carcinoma antigen(SCC-Ag).Methods:30 of 94 patients were treated with concurrent chemoradiotherapy (CCRT).The SCC-Ag levels were measured in 94 patients before treatment, in 30 patients during 3 months after treatment,and at the follow-up.Results:(1)The pretreatment serum levels of SCC-Ag were elevated in 63(67%)patiens,It's sensitivity in detecting the cervical cancer of different histological category is 67%(63/94).(2)The number of patients with an elevated pretreatment SCC-Ag(≥1.5ng/ml)level was associated with the FIGO stage, tumor volume(P＜0.05),was not associated with pelvic lymph node status. When the pretreatment serum levels of SCC-Ag is 4ng/ml,it is associated with the pelvic lymph node status(P＜0.05).(3)The frequency of complete remission (CR)and the normalization of the posttreatment tumor marker were also analyzed.After completing CCRT,the SCC -Ag levels were normalized in almost all patients with an incidence of 86.7%(26/30).Among the patients who gained CR with a previously elevated pretreatment SCC-Ag,the values were normalized in 96%(24/25)after treatment.Conclusion:Assays of the pre- and posttreatment serum SCC-Ag levels appear to be useful for both predicting the prognosis and estimating the clinical response in cervical cancer.