Video-EEG Clinical Analysis Of190Cases Of Patients With Epilepsy

Background:Epilepsy(EPI)is a kind of brain disorder characterized by recurrent,and is also acommon disease of the department of Neurology,difficult to treat.Disease pathogenesisis not entirely clear.The diagnosis of EPI multiply combined with the history andspecificity of clinical symptoms,signs,and except for other reasons.EEG（electroencephalography,EEG）epileptiform discharges is the objective evidence forthe diagnosis of EPI,as well as scientific and objective basis for the prognosis of theEPI.Video-electroencephalography（VEEG） monitoring is a form of EEG.It is adigital camera device monitoring patients’ behavior, at the same time be able to monitorthe EEG activity,greatly improve the detection rate of abnormal EEG,and is animportant method in clinical.EPI is a chronic encephalopathy,the main method of prevention is a long-term useanti-epileptic drugs(AEDs) to control of seizures.It is very important in the treatment ofEPI.In this study,utilizing of VEEG checked190cases of EPI patients,and observedwhether AEDs will affect the epileptiform detection rate of VEEG.Objective:1.Researching the epileptiform detection rate of VEEG in different seizure types ofEPI whether exist difference.2.Investigating Sodium Valproate(VPA）and（Lamotrigine）LTG two kinds ofAEDs whether will affect the epileptiform detection rate of VEEG.Methods:1.Analyzing general information, a detailed medical history, diagnosis andmedication. 2.Typing and medication:2.1Seizure types were divided into five groups:①generalized tonic-clonic seizure(GTCS)92（48.4%）；②complex partial seizure(CPS)38（20%）；③CPS-GTCS45（23.7%）；④simple partial seizure(SPS)6（3.2%）；⑤CPS-GTCS.9（4.7%）.2.2Medications were divided into seven groups:①VPA89（46.8%）；②LGT44（23.2%）；③Topiramate16（8.4%）；④Carbamazepine24（12.6%）；⑤Ammonia los acid tablets11（5.8%）；⑥Levetiracetam4（2.1%）；⑦Phenobarbital2（1.1%）.2.3.Video-EEG results:The results of VEEG were divided into epileptiform discharges162（85.3%）, noepileptiform discharges28（14.7%）.Results:1.EPI clinical analysisGeneral cases: In190cases of EPI patients, I selected108male patients and92female patients with the ratio of27:23. The age ranged from14to79years old withaverage age of38.42±18.02years old.2.Anlyzing the results of VEEG in different seizure types:①GTCS92（48.4%）：epileptiform discharges7(84.8%)，no epileptiformdischarges14(15.2%)；②CPS38（20%）：epileptiform discharges31(81.6%)，no epileptiform discharges7(18.4%)；③CPS-GTCS45（23.7%）：epileptiform discharges40(88.9%)，no epileptiformdischarges5(11.1%)；④SPS6（3.2%）：epileptiform discharges6（100%）；⑤SPS-GTCS9（4.7%）：epileptiform discharges7（77.8%），epileptiformdischarges2（22.2%）。Compared the results of the GTCS、CPS、CPS-GTCS three groups,total175casesof EPI patients,the other groups were in a small number,we would do not make astatistical analysis current. There was no differences in the epileptiform detection rate ofVEEG among the there groups(P>0.05).3.The results of VEEG in different AEDs ①VPA89（46.8%）：epileptiform discharges78（87.6%），no epileptiformdischarges11（12.4%）；②LTG44（23.2%）：epileptiform discharges36（81.8%），no epileptiformdischarges8（18.2%）；③Topiramate,16（8.4%）：epileptiform discharges13（81.3%），no epileptiformdischarges3（18.8%）；④Carbamazepine24（12.6%）：epileptiform discharges22（91.7%），noepileptiform discharges2（8.3%）；⑤Ammonia los acid tablets11（5.8%）：epileptiform discharges（72.7%），noepileptiform discharges3（27.3%）；⑥Levetiracetam4（2.1%）：epileptiform discharges4（100%）；⑦Phenobarbital2（1.1%）：epileptiform discharges（50%），no epileptiformdischarges1（50%）.In this research,the results of VEEG of VPA and LTG two groups,total133casesof EPI patients,the others were in a small number,we would do not make a statisticalanalysis current. There was no difference in the epileptiform detection rate of VEEGbetween the two groups(P>0.05).4.The results of VEEG in different seizure types and AEDsRemoving no statistics of the cases,there were125.4.1GTCS68（54.4%）：①VPA50（73.5%）: epileptiform discharges45（90%），no epileptiform discharges5（10%）；②LTG18（26.5%）: epileptiform discharges14（77.8%），no epileptiformdischarges（22.2%）。Compared the epileptiform detection rate of VEEG between the two kinds of durgs,the difference was not statistically significant(P>0.05).4.2CPS25（20%）：①VPA16（64%）: epileptiform discharges11（68.8%），no epileptiform discharges5（31.3%）；②LTG9（36%）: epileptiform discharges7（77.8%），no epileptiform discharges2（22.2%）。Compared the epileptiform detection rate of VEEG between the two kinds of durgs,the difference was not statistically significant(P>0.05).4.3CPS-GTCS32（25.6%）： ①VPA19（59.4%）: epileptiform discharges18（94.7%），no epileptiformdischarges1（5.3%）；②LTG13（40.6%）: epileptiform discharges11（84.6%），no epileptiformdischarges2（15.4%）.Compared the epileptiform detection rate of VEEG between the two kinds of durgs,the difference was not statistically significant(P>0.05).Conclusion:1. The epileptiform detection rate of VEEG was no significantdifference in different seizure types of EPI.2.There was no significant difference between the epileptiform detection rate ofVEEG in VPA and LTG.