The Clinical And Electrophysiological Study Of Seizure And Epilepsy After Stroke

Background People who have no stroke knowledge are often mistake seizures for the stroke which a-re the same as they occur.stroke is a longer episode and almost always leaves some kind of permanent damage while seizures are usually brief and recover after a short time.Strok-e can affect movement,speech,behavior,memory and emotions.What might be less ob-vious about stroke's effects is the increased chance of seizures.In recent years,stroke has become one of the most important causes of pilepsy,especially in elderly pati-ents with s-troke.Seizure is a common complication after stroke which termed “post-stroke seizure”PSS.Although many studies have assessed outcomes and risk fa-ctors and electrophysiol-ogical characteristics of PSS,no reliable predictors are currently avai-lable to determine PSS recurrence.We compared baseline clinical characteristics,electro-physiologic and p ost-stroke treatment regimens between recurrent and non-recurrent PSS patients to identi-fy independent predictors and hazard factors of recurrence.Methods Consecutive the data with inpatient or outpatient follow-up of post-stroke seizures and epilespsy patients who admitted to our hospital Neurology department stroke center betw een December 2013 and December 2016.Monitored and retrospectively evaluated for ba seline clinical characteristics and recurrence and electrophysiology between recurrent(c-ase group)and non-recurrent(control group)PSS patients.Cumulative recurrence rates a-t 90,180,and 360 days post-stroke were estimated by Kaplan—Meier analysis.Independ-ent predictors of recurrent PSS were identified by Cox proportional-hazards analysis.Results A total of 104 patients(71 men;mean age,72.1 ± 11.2 years)post-stroke seizures rec-ured in 31 pa-tients(30%)during the follow-up were analyzed.Factors significantly asso-ciated with PSS recurrenc-e by log-rank analysis included previous PSS,valproic acid(VPA)mono-therapy,polytherapy with a-ntiepileptic drugs(AEDs),frontal cortical lesion,and higher modified Rankin Scale score at discharge(all p < 0.05).Independent predictors of recurrent PSS were age <74 years(HR 2.38,95% CI 1.02-5.90),VPA monotherapy(HR 3.86,95% CI 1.30 –12.62),and convulsions on admission(HR 3.87,95% CI 1.35 –12.76).