Sleeps With Clinical Study And Mechanism Of Treatment Of Qi And Yin Deficiency Type Insomnia

Purpose: In order to observe the clinical efficacy of the treatment of Yin Deficiency typeof insomnia Shumian paste. Observation Shumian paste mice sleep latency and sleep time,and anti-anoxia, anti-fatigue effect, sedative and hypnotic explore Shumian capsules,anti-fatigue, anti-anoxia pharmacological effect.Method: This study is to take to meet the diagnostic criteria of insomnia (Qi Deficiency)120patients were randomly divided into2groups on the basis of the theory of Chinesemedicine dialectical theory of governance. A group of60patients, to Yinao capsules treatment;60cases in group B, I Shumian paste treatment; statistical analysis, the two groups nodifference in gender, age, size, length of the course, comparable between the two groups are in10days for a course of treatment, continuous observation of three courses. Chinese medicinesymptom evaluation criteria and the Pittsburgh Sleep Quality Index the scale (PSQI) ascriteria in the assessment. Locomotor activity in mice and mice dose of sodium pentobarbitalhypnosis sleep latency and sleep time effects were observed Shumian affixed to the sedativeand hypnotic effects; mouse anti-fatigue test, the effects of hypoxia tolerance test, observedShumian of capsule anti-fatigue and anti-anoxia.Result: A group (Shumian the stickers treatment group) total efficiency of56.66%; B groupthe (Yinao capsule treatment group) total efficiency of73.33%; statistical treatment, P <0.05,significant difference between group B is better thangroup A; especially in the treatment ofinsomnia or more dream fitfully, weary, fatigue, dizziness, tinnitus, dry mouth and throat,dysphoria hot, palpitations, forgetfulness, irritability, red or red tongue, little coating, rapidpulse, orbreakdown on better. Shumian paste can significantly reduce locomotor activity inmice (P <0.05), prolonged sleep time (P <0.05, P <0.001), with statistical significance.Shumian paste each group can enhance hypoxia tolerance in mice under normal pressure, andshowed a dose-dependent manner (P <0.05, P <0.01); mice loaded swimming duration of highand low dose group can be extended (P <0.05).Conclusion: Shumian posted on clinical symptoms and symptom scores were better thanbeneficial brain capsule treatment group, and no adverse reactions and side effects, safe,reliable, effective method for the treatment of insomnia Qi Deficiency Shumian paste. Theposted by Shumian inhibition of locomotor activity of mice intensity and shorten sleep latencysleep time, and mice can enhance resistance to fatigue and hypoxia, has a sedative andhypnotic anti-fatigue effect.