The Effect Of Flurbiprofen Compound Fentanyl For Postoperative Analgesia On Thoracoscopic Lung Cancer Patients’ T Cell Subsets And IL-2, IL-6

Objective:In this study, control study observed flurbiprofen fentanyl for postoperativeanalgesia on peripheral lung lesions undergoing elective thoracic surgery andpostoperative analgesia on T cell subsets and IL-2, IL-6effects.Methods:24cases of ASAⅠ～Ⅱgrade peripheral lung lesions undergoing electivethoracic surgery patients, aged53～67years, were randomly divided into two groupsnumbering methods are implemented intubation inhalation general anesthesia,flurbiprofen ester fentanyl analgesia group (K group) and fentanyl analgesia group (F)of the12cases. Connect surgery controlled intravenous analgesia (PCIA) Pumppurposes postoperative analgesia.Group K: fentanyl0.4mg+flurbiprofen axetil150mg+tropisetron of4mg+0.9%saline diluted to100ml, the load volume to2ml,continuous infusion for2ml/h, controlled administration lock for15min, single dose;2ml/Time.Group F: fentanyl0.8mg+tropisetron of4mg+0.9%saline diluted to100ml,load volume of2ml, continuous infusion dose of2ml/h, controlled administration oflock time is15m in a single dose of2ml/Time.Observed after2,24,48VAS score andrecord adverse reactions.15minutes before induction of anesthesia(T0),after2hours(T1), after24hours(T2), and48hours after surgery (T3) acquisition peripheralvenous blood7ml, the use of flow cytometry measuring T cell subsets, The enzyme-linked immunosorbent assay at each time point serum IL-2and IL-6level.Results:General comparison: two groups of patients age, weight and duration of surgerywas no significant difference (P>0.05).2,24,48hours after the two sets of VAS andadverse reactions was no significant difference (P>0.05).Comparison of T cell subsets: T0when, K, F two groups of patients with CD3+,CD4+, CD4+/CD8+difference without statistical significance (P>0.05); comparedwith T0, two groups of patients in T1CD3+, CD4+, CD4+/CD8+significantly lower than those before anesthesia, the difference was statistically significant (P<0.05).Compared with T1, T2when the K-group of patients with CD3+, CD4+, CD4+/CD8+some recovery, the difference was no significant (P>0.05), Group F, patients withCD3+, CD4+, CD4+/CD8+continues to decline,the difference was statisticallysignificant (P<0.05); at T3, K group CD3+, CD4+, CD4+/CD8+has basically returnedto the preoperative level, compared with T0, the difference was not statisticallysignificant (P>0.05); F group, compared with T0, CD3+, CD4+, CD4+/CD8+difference was statistically significant (P<0.05). CD8+,the difference was notstatistically significant ((P>0.05) at each time point.IL-2compared two groups of patients: T0(preoperative) level of IL-2was notsignificantly different, was not statistically significant (P>0.05). Compared with T0,at T1,the two groups of patients with serum IL-2level showed a significantlydecreasing trend that preoperative differences are significant, statistically significant(P<0.05). Compared with T1, at T2, two groups of patients the levels of serum IL-2increased; But K group is more obvious recovery than F, the difference wasstatistically significant (P<0.05), while Group F recovery is not obvious, thedifference was not statistically significant (P>0.05). T3, the K-group level of IL-2hasbeen restored to T0, the difference was not statistically significant (P>0.05); whileGroup F, T3compared with T0, IL-2, the level difference was statistically significant(P<0.05).IL-6compared two groups of patients: T0(before surgery) was not statisticallysignificant (P>0.05) differences in the levels of IL-6. Compared with T0, at T1, thetwo groups of patients with serum IL-6level has significantly increased, as comparedwith the preoperative, difference obvious, there is statistical significance (P <0.05).Compared with T1, at T2, two groups of patients with serum IL-6levels continue torise, the difference was significant (P <0.05); But up from group F，K group is moresmall amplitude，the difference was statistically significant (P<0.05). T3, K groupcompared with group F of IL-6level recovery closer to T0, the difference wasstatistically significant (P<0.05).Conclusion:Thoracoscopic surgery of peripheral lung cancer patients, the use of flurbiprofen fentanyl analgesia,can significantly reduce the amount of fentanyl analgesia and havea exact analgesic effect; effectively inhibit IL-6after generation and to some extentreduce the body’s inflammatory response and immune injury; reduces postoperativedecrease in IL-2, plays a significant immune protective effect and has a certainpositive role to reduce and prevent lung cancer metastasis，Conducive to therehabilitation of patients.