Influence Of Tamsulosin On The Pharmacokinetics Of Levofloxacin In Plasma, Liver, Kidney And Prostate Of Rats With Acute Bacterial Prostatitis

Objective To study the influence of tamsulosin on thepharmacokinetics of levofloxacin in plasma, liver, kidney and prostate ofrats model with acute bacterial prostatitis (ABP).Methods Ninety-six rats model with ABP were randomly assignedinto two groups: experimental group (treated with both tamsulosin andlevofloxacin, n=48) and control group (treated with levofloxacin andsolvents, n=48). Six rats from each group were sacrificed to collect theirblood, liver, kidney and prostate samples to extract plasma or make tissuehomogenate at time points of0.125,0.25,0.5,1,2,4,8and12h after drugadministration. The levofloxacin concentrations were detected by highperformance liquid chromatography (HPLC) methods and thenpharmacokinetic parameters were calculated using3p97software program.Results There were not significant difference (P>0.05) between theexperimental and control groups in the major pharmacokinetic parametersof levofloxacin, including half-time (t1/2), time to peak (tpeak), clearance rates (CL), maximum concentration (Cmax) and area under the curves(AUC0～12) in plasma, hepatic and kidney tissues of those model rats.However, in prostate tissues, tamsulosin significantly increased the Cmax,prolonged the t1/2and decreased the CL of levofloxacin (P<0.05).Conclusion Tamsulosin could obviously increase the concentration andprolong drug elimination time of levofloxacin in the prostate of rats modelwith acute bacterial prostatitis, while in plasma, liver and kidney tissuesthere was no noticeable difference, suggesting that tamsulosin may enhancethe effect of levofloxacin in the treatment of acute bacterial prostatitiswithout changing the drug load of liver and kidney.