Clinical Analysis Of Blood Coagulation Function State Of Bronchial Asthma Patients

Objective: By comparing the coagulation functions of the asthma patients withdifferent courses of disease, get to know the features of coagulation functions of thosepatients as well as the difference (if any), analyze the possible causes for variation of theircoagulation functions, and provide a theoretical foundation for application of the relevanttherapy for adjusting the coagulation functions in asthma treatment. Method: By carryingout a retrospective case-control study, collect the clinical data, including age, sex, courseof disease, and other data like PT, INR, FIB, APTT, TT, etc., of222patients who arechosen in accordance with the inclusion and exclusion criteria. Divide the patients intothree groups based on their courses of disease and divide each group into Group A and Baccording to their age, and then compare the indicators listed above between each otheramong those groups. Results: For the patients with their disease courses more than10years, as shown by the comparison of their coagulation functions with those of the patientswith their disease courses less than1year or ranging from1to9years, each indicator hasa statistic difference (P＜0.05), which indicates that the disease gets more serious beforeformation of thrombus. Compared to the patients with their disease courses less than1year, the patients with their disease courses ranging from1to9years have decreased PT,INT and TT. For the nonelderly patients, the fibrinogen increases significantly and thedecrease TT is distinctive; for the elderly patients, the difference of fibrinogen and thedecrease of TT have no statistical significance. Conclusion: For the patients of bronchialasthma, the increase of their disease courses is relevant to their increasingly higherhypercoagulability. As shown by the comparison among those groups, PT, PTA and INRall have a statistic difference, which may result from the whole body’s higher sensitivity to the extrinsic pathway of blood coagulation caused by the variation of local coagulabilityof lung. In each group of nonelderly patients, the coagulability changes more significantly,and for the patients with over-10-year disease courses, the fibrinogen increasessignificantly and the decrease of APTT and TT is distinctive; for the elderly patients, thedifference of fibrinogen and the decrease of TT have no statistical significance. Theasthma patients’ hypercoagulability becomes increasingly higher along with thedevelopment of their disease courses. Hence, we should attempt to provide an appropriateanticoagulant therapy for the asthma patients, thus having a better control over the asthma,deferring the development of their disease courses, preventing or mitigating itscomplication, and improving their life quality.