| Objective: This topic to be adopted by the guinea pig animal experiments to observethe cool Bimin capsules guinea pig model of allergic rhinitis symptoms, nasalpathological and serum histamine content; analysis of its effectiveness,.Methods:60guinea pigs were randomly divided into model group10, prednisoneacetate tablets group (positive control group),10in the experimental group (high,medium and low dose group)30and the blank group10. Among them, the modelgroup, positive control group and experimental group using ovalbumin model. Thesuccessful modeling from the day after, model group, positive control group, theexperimental group administered continuously for15days, The blank group does notdo any treatment, symptoms change observed.①Each group before and afteradministration.②Each group after the administration of pathological changes of thenasal mucosa.③Serum histamine in guinea pigs after administration.Results:①The Biminshuang capsule, the low-dose group can improve the symptomsof allergic rhinitis in guinea pigs, with the positive control group, no significantdifference (P>0.05);②Biminshuang capsule high, medium and low dose group,three groups can significant improvement in the guinea pig model of nasalhistopathological damage, reduce inflammatory cell counts, the light microscopeinflammatory cells ratings compared with model group significantly decreased (P<0.05)③Biminshuang capsule high, medium and low dose group can reduce thehistamine content in the serum of a guinea pig model, the effect of prednisone acetatetablets considerable (P>0.05).Conclusion: Biminshuang capsules on guinea pigs with allergic rhinitis symptoms,nasal pathological significant improvement, Bimin cool capsule can significantlyreduce histamine in allergic rhinitis guinea pig serum. Particularly, the effect of low-dose group, its efficacy and prednisone acetate tablets considerable. |
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