| Objective:To discuss the existence of abnormal lipid metabolism in patients with subclinical hypothyroidism and to analyze its relationship between the patients and the possible vascular lesions,and to provide the basis for the treatment and prevention of the possible vascular damage in subclinical hypothyroidism patients.Method:1.According to the inclusion and exclusion criteria,a total of 239 subclinical hypothyroid patients who were treated at the People’s Hospital of Jiangxi Province from March 2013 to March 2017 were selected as the observation group.This group of patients was the first to find and had not used thyroid hormone drugs.A total of 126 patients with normal thyroid function matched with the age and sex of the observation group who were physically examined at the physical examination center of Jiangxi Provincial People’s Hospital were selected as control groups.Observed indicators include: gender,age,height,weight,SBP,DBP,FPG,2hPG,LDL-C,HDL-C,TC,TG,TSH,TT4,FT4,and C-IMT.Previous history of smoking,drinking history,cardiovascular disease(Refers to hypertension and coronary heart disease)etc.2.To analyze the gender and age distribution of subclinical hypothyroidism in the observation group,compare the abnormalities of lipid metabolism in the two groups,and analyze the relationship between lipid metabolism disorder and C-IMT in subclinical hypothyroidism patients.Result:1.In the final analysis,239 cases were observed in the observation group,including 142 females(59.41%)and 97 males(40.59%),A total of 126 patients in the control group,including 80 females(63.49%)and 46 males(36.51%).Baseline data analysis showed that there was no significant difference in age,gender,and body mass index between the two groups(P>0.05).2.Compared with the control group,the levels of TC and TG in the subclinical hypothyroidism group were significantly increased(t = 2.179,P = 0.030;t = 5.581,P <0.001);There was no significant difference in LDL-C and HDL-C levels(t=1.887,P=0.060;t=1.798,P=0.073).3.Compared with the control group,when TSH≥10μIU/ml,there was a positive correlation between TSH levels and TG,TC,and LDL-C levels,the difference was significant(P<0.05),and there was no significant difference between HDL-C levels and TSH levels(P>0.05).4.The Pearson method was used to analyze the relationship between genderspecific TSH levels and blood lipids.Partial correlation analysis of TSH with TG,TC,LDL-C,HDL-C and other indicators was performed after controlling age,height,and BMI confounding factors.Compared with groups,TSH level was positively correlated with TG and TC levels in women with subclinical hypothyroidism patients,(r=0.21 and r=0.045,P<0.05),and TSH levels was positively correlated with TC level in male with subclinical hypothyroidism patients(r=0.023,P<0.05).5.In women with subclinical hypothyroidism patients,dyslipidemia prevalence increased year by year in 40-79 years and men decreased year-on-year.The prevalence of triglyceride and total cholesterol in women with subclinical hypothyroidism patients aged 50-69 were all above 30%.Male patients were in 20 %the above.6.Among subclinical hypolipidemic patients,80 patients with C-IMT ≥1.0 mm accounted for 60.15%;53 patients with <1.0 mm accounted for 39.85%.HDL-C level and C-IMT were negatively correlated,with significant differences(P<0.05),the lower the HDL-C level,the greater the risk of C-IMT.No correlation was found between TG,TC,and LDL-C levels and C-IMT(P>0.05)7.This study showed that the triglyceride in the group with cardiovascular disease was significantly higher than that in the group without cardiovascular disease in subclinical hypothyroidism patients(1.60±0.95 vs.1.25±0.78,P=0.046).There was no significant difference in the levels of TC,LDL-C and HDL-C between the two groups(P>0.05).8.Analyzed the factors that affected the lipid levels in subclinical hypothyroidism with Logistic regression analysis and found that gender and smoking were risk factors for HDL-C disorders(P=0.004,OR=2.413,95%CI: 1.321-4.408;P= 0.016,OR=2.268,95% CI: 1.163-4.425;P=0.001,OR=3.755,95% CI: 1.781-7.918).BMI increases the risk of elevated TG in patients(P=0.000,OR=1.203,95%CI:1.085-1.332);Drinking reduces the risk of TC elevation in patients(P=0.042,OR=0.325,95% CI: 0.110-0.961).Conclusion:1.Patients with subclinical hypothyroidism have disorders of lipid metabolism,with elevated levels of TC and TG.2.Abnormal lipid metabolism in subclinical hypothyroidism may increase the risk of C-IMT.3.The gender,smoking and increase in body mass index are risk factors for lipid metabolism disorders in subclinical hypothyroidism patients. |
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