Expression And Relation Of DEK And E-Cadherin Protein In Bladder Cancer

Objective:Bladder cancer (BC) is the most common malignancy of the urinary tract and one of the most frequent cancers worldwide. BC represents the sixth cause of dis-ease and the second urological malignancy after prostate cancer; moreover, BC is the most common urological tumor in China Recurrence with metastasis is a frequent cause of death, with some studies highlighting this phenomenon in up to70%of pa-tients. Indeed, overall tumor-specific5-year survival rate for years2002-2008is around77%, but it is only5.5%after cancer has metastasized (NCI, June2012). The objective of this study was to analyze the presence of DEK protein and E-cadherin in bladder cancer patients and to find the role of DEK and E-cadherin in bladder cancer and also to find the correlation between DEK and E-cadherin in relation to bladder cancer.Methods:We examined the expression of DEK protein and E-cadherin by immmu-nohistochemistry in50bladder cancer tissue samples. The presence of DEK protein and E-cadherin was analyzed by immunohistochemistry in samples collected from patients with bladder cancer.Results:There were50bladder cancer samples. Based on our sample size, DEK pro-tein was abnormal (high) in58.82%and90.90%of Low grade and High grade blad-der cancer samples respectively, whereas E-cadherin was abnormal (low) in29.41%and75.75%of Low grade and High grade bladder cancer samples respectively. Dek protein was abnormal (high) in66.66%and84.42%in superficial and invasive bladder cancer samples respectively, whereas E-cadherin was abnormal (low) in33.33%and68.42%in superficial and invasive bladder cancer samples respectively.Conclusion:Based on our study of50bladder cancer tissue samples. DEK protein and E-cadherin is expressed in bladder cancer tissue of bladder cancer patients. The presence of DEK protein and E-cadherin in bladder cancer tissue might be associated with the development of bladder cancer and bladder cancer metastasis. In this study we saw that the difference of protein expression level of DEK protein in between dif-ferent grades and stages of bladder cancer.Also the difference of protein expression level of E-cadherin in between different grades and stages of bladder cancer tissue. The protein expression level of DEK is negatively correlated with protein expression of E-cadherin. The protein expression level of DEK is positively correlated in bladder cancer whereas, protein expression level of E-cadherin is negatively correlated with the bladder cancer.Hence we can conclude that in tumor specimens with high malig-nancy has low e-cadherin expression and high DEK expression, indicating increase in the invasiveness and proliferation of the cancer cells...