Association Of Genetic Polymorphism Of Transforming Growth Factorβl With Acute Coronary Syndrome In Han Nationality

Objective：Acute Coronary Syndrome is a complex multifactor and Polygenic disorderthat is thought to result from an interaction between an individual’s genetic makeup andvarious environmental factors, TGF-beta signaling is capable of regulating many of thekey aspects of atherosclerosis and restenosis: inflammation, chemotaxis, fibrosis,proliferation, and apoptosis. There are significant decreases in TGF-beta activity inPatients with atherosclerosis, and equally important changes in the way cells respond toTGF-beta during atherogenesis，Some evidence showed that the mutation of C to T singlenucleotide polymorphism at the-509Position （-509SNP, Rs1800469） is associated withthe secretion, aggregation and activation of TGF1[3-5].the purpose of this study was toinvestigate transforming growth factorβ1polymorphism（-509C>T） and its interactionbetween Acute Coronary Syndrome（ACS） Patients in Chinese population from Xinjiang.Methods: Clinical data: Acute coronary syndrome group: a total of336PatientshosPitalized in the heart center of the First Teaching Hospital of Xinjiang MedicalUniversity from January2006to October2010, which include201male Patients and135female patients,The control grouP was composed of396healthy people with negativecoronary angiography results and no history or family history of cardiovascular diseases,including231male and165female.336Patients with acute coronary syndrome and396healthy control subjects were detected by polymerase chain reaction and restrictionfragment length polymorphism,consequence:The genotype distributions of the controlgrouP and acute coronary syndrome group were in the Hardy-Weinbergequilibrium（χ²=3.54，1.72，P=0.06,0.19）.The frequencies of CC, CT and TT were22.64%, 53.57%and23.80%in acute coronary syndrome group while ones were9.09%,48.74%and42.17%in controls. There was significant difference in frequencies of CC genotypeand C allele between controls and acute coronary syndrome cases(P=4.05×10^-7，P=6.16×10^-10). Conclusion： There results suggest that promoter （-509C>T）polymorphism of ACS is associated with acute coronary syndrome in this population,The CC genotype and C allele of transforming growth factorβ1might be a risk factor ofacute coronary syndrome in Chinese population in Xinjiang. While this study showed thatT allele Plays a leading role in the occurrence of acute myocardial infarction in people ofHan ethnicity in Xinjiang...