PET/CT, Electronic Bronchoscope And Tumor Markers In The Diagnosis Application Of Lung Cancer

Objective:Discuss the application value of PET/CT,electronic bronchoscopy anddetection of tumor markers in diagnosis of lung cancer, and conduct a comparativeanalysis. Methods:Collect68cases of the patients who were found to have lung lesions inthe examination conducted by the PET/CT center of our hospital during the period fromMay2011to May2012, and carry out detection of tumor markers, electronicbronchoscopy or the pathological and cytological examination through percutaneous lungbiopsy or surgical biopsy for all the patients involved. Results:In the68patients, there are37patients with lung cancers and31patients with benign lung lesions, all confirmedpathologically. For diagnosis of lung cancers, the sensitivity, specificity and accuracy ofPET/CT examination are83.8%,83.9%and83.8%respectively; the sensitivity, specificityand accuracy of electronic bronchoscopy are62.2%,100%and79.4%respectively; andthose items for combined detection of tumor markers are75.7%,77.4%and76.5%respectively. In addition, the sensitivity, specificity and accuracy are91.9%,77.4%and85.3%respectively for combined application of PET/CT and detection of tumor markers,and89.2%,77.4%and83.8%respectively for combined application of electronicbronchoscopy and detection of tumor markers, for diagnosis of lung cancers.Conclusions:The specificity of electronic bronchoscopy is higher than the specificity ofPET/CT examination, but its sensitivity and accuracy are lower than those of PET/CTexamination. Moreover, PET/CT has an obvious advantage in examination of smallpulmonary lesions, hard-to-sample lesions in transbronchial lung biopsy and metastaticlesions. Although the combined detection of tumor markers may improve the sensitivityand accuracy for diagnosis of lung cancers, it cannot support a diagnosis identifying theaccurate nature and location of a lung disease, thus it only serving as an auxiliary examination method. For diagnosis of lung cancers, both the application of PET/CTcombined with detection of tumor markers and the application of electronic bronchoscopycombined with detection of tumor markers have a much higher sensitivity and accuracythan a single PET/CT examination, electronic bronchoscopy and detection of tumormarkers, which may reduce the occurrence of wrong diagnosis and missed diagnosis..