Retrospectively Analyzed The Related Factors Of Anemia In170Lung Cancer Patients

Objective：To analyze the correlation between anemia and the related factors,suchas gender,age,clinical stage,serum albumin levels,chemotherapy,and surgery in patients with lung cancer.Methods: Clinical data from March2007to December2010period of170patients with lung cancer were retrospectively analyzed in our hospital. According tothe patient’s age,gender,clinical stage,serum albumin levels, chemotherapy or not,thehemoglobin level, surgery or not many factors such as information.Through theSPSS17.0statistical software, application Logistic regression analysis to a regressionmodel, compare lung cancer with anemia with lung cancer without anemia group,analyze the relationship between the relevant factors and incidence of anemia.Results: A total of170cases of lung cancer patients, there were106casesin patients with anemia.The incidence of anemia was62.4%.According to theWHO anemia degree classification: the mild anemia has56cases, accounting for32.9%;the moderate anemia has43cases, accounting for25.3%;the severe anemia has6cases, accounting for3.5%;the extremely severe anemia has1cases, accounting for0.6%. Compare lung cancer with anemia with lung cancer without anemia group：①The difference of anemia incidence between male and female was not significant(P>0.05).②The difference between age and anemia incidence wassignificant(P<0.05).Among them, patients under the age of50has12cases, theincidence of anemia was33.3%;patients between50~59years old has62cases,the incidence of anemia was50.0%;patients between60~69years old has58cases,the incidence of anemia was69.0%;over the age of70patients has38cases,the incidence of anemia was81.6%.③The difference between clinical stages and anemia incidence was statistical significant(P<0.01).Among them, I stage patient an emia has2cases,accounting for10%(2/20); II stage patient anemia has11cases,accounting for37.9%(11/29); III stage patient anemia has51cases,accounting for69.9%(51/73); IV stage patient anemia has42cases,accounting for87.5%(42/48).④The incidence of anemia in patients with hypoalbuminemia was obviously higher than that in patients with normoproteinemia(87.8%vs42.7%).There is a statistical significance between serum albumin levels and anemia rate(P<0.01).⑤The incidence of anemia in patients received chemotherapy was higher than that in patients who had not received chemotherapy(68.8%vs44.4%).The difference between chemotherapy and anemia incidence was statistical significant(P<0.01).⑥The incidence of anemia in patients received surgery was higher than that in patients whohad not received surgery(76.1%vs57.3%).The difference between surgery and anemia incidence was statistical significant(P<0.01).⑦Whether anemia as the dependent variable Y,the risk factors were defined as:X1age;X2clinical stage;The X3serum albumin levels;X4chemotherapy;X5surgery.Using more arguments Logisticstep-back method to analyze,four risk factors finally entered into the model ofLogistic regression：clinical stage,serum albumin levels，chemotherapy and surgery，these factors has a statistical significance(P<0.05),other variable coefficient hasno statistical difference(P>0.05).Conclusion:The anemia incidence was higher in lung cancer patients,and mainlymild-to-moderate anemia.The study found that,in the related factors affecting lungcancer, anemia was closely related to clinical stage,serum albumin levels，chemotherapy and surgery.The later clinical stage,the lower of serum albuminlevels,received surgery, the higher of the incidence of anemia.Logistic multivariateregression analysis confirmed that clinical stage,serum albumin levels,chemotherapyand surgery are the risk factors in anemia(P<0.05).