Correlative Factors Of Anemia In Non-small Cell Lung Cancer Patients And Its Impact On Prognosis

Objective: Malignant tumor is one of the current diseases that threats tohuman health. In recent years, along with the rapid growth of social economy,environment and people lifestyle changes, the rising incidence of malignanttumor and the mortality rate has become the first cause of death among urbanresidents. Now each year about162.87/10thousand people have died becauseof malignant tumors, the average annual growth rate is5.13%.The prognosisof lung cancer is poor, Non-small-cell lung cancer (NSCLC) accounts forabout80%of the total number of lung cancer.Although with the developmentof molecular biology, targeted therapy to patients with adanced NSCLCcarcinoma saw the light, the overall5year survival in patients with advancedlung cancer is still around10%. After diagnosis, patients with lung cancer notonly bear the pain of disease, but also burden a variety of anti-tumor treatmentside effects. Anemia, as the most common complication during the course ofdisease, is not only affects the patients’ quality of life, but also affect theconventional anti-tumor treatment of tumors, and is closely related to thesurvival of patients’ prognosis.This study used a retrospective researchmethod, through the investigation of anemia in patients with non-small celllung cancer status, distribution characteristics, from the disease diagnosis,analysis of general situation and treatment of anemia occurred related factors,and prognosis of anemia in patients with non-small cell lung cancer survival,thus cause the attention of clinicians to cancer-related anemia, improve the lifequality and improve the prognosis of patients with cancer.Methods: Collected medical records of non-small cell lung cancerpatients during January2008to November2012for the first time admitted bythe fourth affiliated hospital of hebei medical university hospital, to diseasediagnosis,(pathology type and stage), general data (gender, age, PS score, serum albumin level) and treatment information and established a database,application spssl3.0statistical software for data analysis. For all variables toadopt frequency, frequency and other descriptive analysis. Analyzed with X2test (chi-square test) between groups count data. Through the binary Logisticregression analysis to discuss the relationship between anemia in patients withnon-small cell lung cancer and its occurrence influencing factors. Bytelephoned follow-up of patients with the time of death, and applied survivalanalysis to discuss how cancer-related anemia influenced survival prognosis inpatients with non-small cell lung cancer.Results: We eventually chose473qualified cases, the results were asfollows:1General data analysis: male,339cases (71.67%), female,134cases(28.33%); male age (59.98+0.51), the median age was60; women aged(56.97+1.0), the median age was58.5years old.2Disease data analysis: the pathological types, included243cases ofsquamous cell carcinomas (51.37%),225cases of adenocarcinoma (47.57%),and5cases of other types (1.06%); pathological stages: stage I,35cases(7.4%), stage II,52cases (11.0%), stage III,148cases (31.29%), stage IV,238cases (50.31%).3Treatment data analysis: in recent treatment,29cases of operation,381cases of chemotherapy,63cases of radiation therapy,23cases of targetedtherapy,4cases of biological treatment,5cases anti-infection treatment.4Situation of anemia: totally273patients with anemia (57.72%),200cases (73.26%) of men,73cases(26.74%) of women.There were183cases ofmild anemia,82cases of moderate anemia,8cases of severe anemia, the totalrate of mild-to-moderate anemia was97.07%; Albumin levels <35g/L was195patients (41.23%), of which157cases of anemia, accounted for57.51%of anemia patients.5Anemia related factors analysis: by X2test, lung cancer anemiaoccurred differently in age (X2=3.459, P=3.459), albumin level (X2=70.648,P=70.648), PS score (X2=10.222, P=10.222), whether did recent surgery (X2=4.956, P=4.956), whether did recent chemotherapy (X2=3.627, P=0.037), and other factors. By multiple factors analysis, hypoalbuminemia wasan independent risk factor for anemia;6Prognosis analysis: we did follow-up to427patients with non-smallcell lung cancer in473cases, the follow-up rate was90.28%(427/473),patients’ overall survival time (Over all survival, OS) was2~64month, themedian OS was16months. Of anemia in patients with a median OS for15months, without anemia in patients with a median OS for17months, withoutanemia in patients with a median OS than the extension of anemia in patientswith2months, there was a difference between the two (P=0.017).Conclusion:1The single factor analysis showed that age, serum albumin levels, PSscore factors had a close relationship with anemia.Sex, tumor staging andpathologic type was not associated with the occurrence of anemia. In terms oftreatment, whether did recent surgery and chemotherapy was associated withanemia. Radiation therapy, targeted therapy, biological therapy andanti-infection treatment has nothing to do with anemia.2Multi-factor analysis showed that hypoalbuminemia is an independentrisk factor of anemia.3Survival of anemia patients with non-small cell lung cancer wasclosely related to the occurrence of anemia, it was the prognosis indicator ofshorten survival period in small cell lung cancer patients, and it was anindependent factor of prognosis in patients with small cell lung cancer.