For the present problem of high incidence of disease at later stages, slow weight gain in livestock and poultry breeding industry, antibiotics and some chemical synthetic drug are used by most of the farms,but the control effect in not perfect, and that is easy to produce drug resistance and drug residues.On account of Chinese herbal medicine has the effect of supplying growth factor,improving immunity of the organism and reducing morbidity. Based on Chinese veterinarian theory, Characteristics of simple and easy operation of effervescent tablets are combined in this paper, we use compound Chinese herbal medicine formulation of effervescent tablets which is developed by modern preparation technology and has the peculiarity of unique curative effect, small side effects, low residual, easy to use and high biological utilization.we selected the following aspects to study:the establish of the prescription of the compound Chinese herbal medicine effervescent tablets and supplementary material, research of preparation technology, quality standard, clinical test weight and effect of observation of late poultry disease prevention.1. According to the vision, red sage root, dried tangerine or orange peel, the divine comedy, platycodon root,mulberry, baikal skullcap root seven TCM has antiviral, anti-inflammatory, enhance immunity and growth promoting role; Merger of seven flavor of Chinese herbal medicine extracts, no precipitation, change color reaction. Polygala, salvia miltiorrhiza, dried tangerine or orange peel, the divine comedy, platycodon root, mulberry, radix scutellariae (1:1:1:2:2:1:2) prescription for traditional Chinese medicine.2. By orthogonal experimental design optimize the influence of effervescent tablets agent mainly accessories, choose the best matching:the extract of Chinese herbal medicine powder180g, tartaric acid140g, sodium bicarbonate70g, starch80g, microcrystalline cellulose40g, according to a2010department of veterinary drug standard used to establish the scope of the standard in this test10g magnesium stearate,10g of the micro-powder silica gel,70g of PEG6000,30ml5%PVP K30anhydrous ethanol solution.3. Natural storage for3months, the sample of the stability test method, the temperature of37℃and75%relative humidity environment measurement traits of effervescent tablets agent, PH value, weight difference, and disintegration time limit all the indicators are in line with the2010edition of "the Chinese veterinary drug standard" regulation.4. We use1.5g (3pieces),2g(4pieces),2.5g (5pieces), comparing the three gradient of dose to initial weight and the weight for the determination of indicators, to determine the chicken dose of2g/L (3pieces). Using SAS8.2software version of the statistical software analysis experimental broiler weight difference significant (P<0.01) and control group in broilers of weight difference is not significant (P>0.05).5. Via analyzing the incidence of12only chicken, chicken no macroscopic observation test group, control group in the incidence of broilers was50%, showed the compound Chinese herbal medicine effervescent tablets to broilers diseases frequently during late growth has good preventive effect.6. By the analysis of the pathological control group lung tubular accidentally see leukocyte infiltration, little visible blood capillaries around the pipes. Liver cells have vesicular degeneration phenomenon. No obvious pathological change in experimental group. |