Gas Injection For Reasons After Vein (lyophilization) Treatment Of Coronary Heart Disease Angina Pectoris (qi And Yin Deficiency Syndrome) Clinical Study

Purpose：This trial for further evaluation its gas injection complex veins(freeze-dried) treatment of coronary heart disease, angina (two gas Yindeficiency syndrome) safety and efficacy of clinical trials.Material and method：1Clinical data: This test in liaoning university of Chinese medicine affiliatedhospital of traditional Chinese medicine for selecting the syndromedifferentiation gas Yin deficiency syndrome patients with obstruction of thetwo as observation card type, a total of43patients with observation.2The preparation method: to its gas injection complex veins (freeze-dried),(5.2g/time, namely8bottles/time); With250ml5%glucose injection dilutedsaline or intravenous injection, about40drops per minute,1time/day, thetreatment period for two weeks. In the clinical trials allowed to keep itsexisting Chinese and western medicine in the treatment of coronary heartdisease. But must write the combination of Chinese and western medicine bythe brand name, chemical name (refers to the western medicine), usage anddosage, treatment and so on, and in the clinical trials remain unchanged. Forother diseases and joint use of drugs, please also indicate the aboverequirements.3Observation index: patients each check before and after treatment a routineblood, urine and move bowels regular, liver function (AST, ALT), kidney (BUN,Cr), blood sugar inspection, ecg, Seattle angina pectoris scale;(1) safetyobservation index: before and after treatment for each one, and should beclosely observe the emergence of adverse reactions, and make records, liverand kidney function when the group has damage in patients after7days increasea kidney and liver function examination.(2) the curative effect of observationindex: electrocardiogram, Seattle angina pectoris scale in before and after the drug treatment each check one time. Vital signs and anginal attacks, anginapectoris grading change, nitroglycerin consumption and reduce stop rate, thecurative effect of TCM syndrome in drug use, drug situation before7days afterthe end of each examination and treatment after all.4Statistical methods: the Epidata3.0for data entry and management, statisticsanalysis by SPSS11.5and SAS8.2completed. All that bilateral inspectionby statistics, inspection standards ɑ=0.05. According to data types andindex category choose corresponding statistical methods.Results：1Before and after treatment classification comparison angina pectoris: aftertreatment, angina pectoris classification and reduce attack frequencydecreases, and more statistically significant before treatment (P＜0.05).2Seattle angina pectoris scale: after treatment, the patient body campaign islimited degree, angina pectoris stable state, heart attacks, treatmentsatisfaction, disease understanding than that of before treatment change (P＜0.05).3Electrocardiogram curative effect situation:40cases after treatment,effective21cases, powerfully in2cases, invalid in16, aggravating in1,and electrocardiogram GaiShanLv for57.5%.4Nitroglycerin and stop taking reduced rate:40cases, with16patients didnot use nitroglycerin, users nitroglycerin stop reduction rate is85%.5Clinical curative effect of traditional Chinese medical syndrome:40casesafter treatment,20cases got, effective in13, invalid in6, increase in1,TCM symptoms GaiShanLv curative effect for82.5%.6Safety evaluation: after treatment, the general medical examination, routineblood, urine and kidney function are not see apparently unusual. Only1patientliver function is unusual, before treatment cereal third transaminase (ALT)9U/L, aspertate aminotransferase (AST) and U/L; After treatment, the ALT256U/L, AST159U/L, consider medicaments sex liver damage, to protect liver9 d treatment in hospital after liver meritorious service is back to normal (ALT19U/L AST,23U/L), did not see the other patients experienced the bad.Conclusion：coronary heart disease, Traditional Chinese Medicine Therapy,Reference extract of YiQiFuMai for injection, Clinical ResearchReference extract of YiQiFuMai for injection (freeze-dried) treatment ofcoronary heart disease, angina (gas Yin deficiency of both type) used forclinical is safe and effective, did not see the obvious side effects, laboratorysafety index also did not find apparently unusual, clinical curative effect oftraditional Chinese medicine symptoms improved obviously,worth in clinicalspread the use of it.