Major Bupleurum Particles To Prevent Stroke Acute Lung Infection In Clinical Research

ObjectiveTo clear the effectiveness and the possible mechanisms that Dachaihu granules on the prevention of pulmonary infections of patients with acute stroke.MethodsThe study included60cases of the acute phase of stroke; patients were randomly divided into prevention group and control group of30cases. The two groups were given basic treatment. Turn over bedridden patients from time to time, patting back, routine sucking sputum,etc. Prevention group:treatment on the basis of the control group, the Dachaihu granules were taken orally. After the treatment for one week or pulmonary infections diagnosised to stop observations, and checked the statistical evaluation and assessed the National Institutes of Health Stroke Scale (NIHSS) scores and traditional Chinese medicine symptom scores at the beginning and the ending of the treatment.Results1. Baseline comparison of the prevention group and the control group Age, sex, type of the stroke, past medical history of prevention group and control group had no significant difference (P>0.05); NIHSS scores and traditional Chinese medicine symptom scores in the two groups before treatment had no significant difference (P>0.05). The two groups of patients had comparable basel ine.2. Evaluation of the efficacy of the prevention group and control group:The incidence of pulmonary infection of prevention group patients was16.7%and40%in the control group, the results of two groups compared had a statistically significant difference (P<0.05); NIHSS scores and traditional Chinese medicine symptom scores had improved within each group, there was statistically significant difference (P<0.05). Between two groups there was no statistically s ignificant difference (P>0.05), but the prevention group compared with control group scores improved at a large extent; immune and inflammatory markers within the groups and between the groups difference was not statistically significant (P>0.05).3. Six meridians differentiation and viscera differentiation reflected concrete evidence and property of patients’manifestations in the acute phase stroke,declared that Six meridians differentiation had important value on clinical and scientific research of stroke Conclusion1. The dachaihu granules can prevent pulmonary infection in the acute phase of stroke effectively.2. Six meridians differentiation and viscera differentiation reflected concrete patterns of symptom and treatment in the acute phase stroke, can provide new ideas to stroke research.